{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:03:51Z","timestamp":1790816631697,"version":"4.1.0"},"reference-count":12,"publisher":"SPIE-Intl Soc Optical Eng","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:p>We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53\u00b10.16  mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS.<\/jats:p>","DOI":"10.1117\/1.3146813","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T18:07:10Z","timestamp":1244052430000},"page":"1-3","source":"Crossref","is-referenced-by-count":24,"title":["Intraluminal fluorescence spectroscopy catheter with ultrasound guidance"],"prefix":"10.1117","volume":"14","author":[{"given":"Douglas N.","family":"Stephens","sequence":"first","affiliation":[{"name":"Univ. of California, Davis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesung","family":"Park","sequence":"additional","affiliation":[{"name":"Univ. of California, Davis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Univ. of California, Davis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanassis","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-0748","authenticated-orcid":false,"given":"Laura","family":"Marcu","sequence":"additional","affiliation":[{"name":"Univ. of California, Davis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"10.1117\/1.3146813_r1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.551804"},{"key":"10.1117\/1.3146813_r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.02.010"},{"key":"10.1117\/1.3146813_r3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.atherosclerosis.2008.08.035","volume":"204","author":"Marcu","year":"2009","journal-title":"Atherosclerosis","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9150","issn-type":"print"},{"key":"10.1117\/1.3146813_r4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000029927.92825.F6"},{"key":"10.1117\/1.3146813_r5","doi-asserted-by":"publisher","DOI":"10.1117\/1.2190967"},{"key":"10.1117\/1.3146813_r6","doi-asserted-by":"publisher","DOI":"10.1161\/hc0802.104291"},{"key":"10.1117\/1.3146813_r7","doi-asserted-by":"publisher","DOI":"10.1364\/OL.21.000912"},{"key":"10.1117\/1.3146813_r8","doi-asserted-by":"publisher","DOI":"10.1364\/AO.44.004722"},{"key":"10.1117\/1.3146813_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2007.08.001"},{"key":"10.1117\/1.3146813_r10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.540013"},{"key":"10.1117\/1.3146813_r11","doi-asserted-by":"publisher","DOI":"10.1063\/1.1634354"},{"key":"10.1117\/1.3146813_r12","doi-asserted-by":"publisher","DOI":"10.1364\/OL.33.000630"}],"container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-14\/issue-03\/030505\/Intraluminal-fluorescence-spectroscopy-catheter-with-ultrasound-guidance\/10.1117\/1.3146813.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:34:53Z","timestamp":1790814893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-14\/issue-03\/030505\/Intraluminal-fluorescence-spectroscopy-catheter-with-ultrasound-guidance\/10.1117\/1.3146813.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,1]]},"references-count":12,"journal-issue":{"issue":"03"},"URL":"https:\/\/doi.org\/10.1117\/1.3146813","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,1]]}}}