{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:03:39Z","timestamp":1790816619876,"version":"4.1.0"},"reference-count":20,"publisher":"SPIE-Intl Soc Optical Eng","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:p>Because of the increasing incidence of skin cancer, interest in using the autofluorescence of skin tissue as a noninvasive tool for early diagnosis is enforced. Focus is especially on malignant melanotic melanoma. On the basis of a newly developed method to selectively excite melanin fluorescence of skin tissue by stepwise two-photon excitation with nanosecond laser pulses at 810  nm, we have investigated information from this melanin fluorescence with respect to the differentiation of pigmented lesions. A distinct difference in the melanin fluorescence spectrum of malignant melanoma (including melanoma in situ) when compared to that of benign melanocytic lesions (i.e., common nevi) has been found for freshly excised samples as well as for histopathological samples. There is also specific fluorescence from dysplastic nevi. In this way, early detection of malignant melanoma is possible.<\/jats:p>","DOI":"10.1117\/1.3155511","type":"journal-article","created":{"date-parts":[[2009,6,17]],"date-time":"2009-06-17T18:03:50Z","timestamp":1245261830000},"page":"1-7","source":"Crossref","is-referenced-by-count":40,"title":["Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence"],"prefix":"10.1117","volume":"14","author":[{"given":"Reinhold","family":"Eichhorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Wessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Scholz","sequence":"additional","affiliation":[{"name":"LTB Lasertechnik Berlin GmbH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Leupold","sequence":"additional","affiliation":[{"name":"LTB Lasertechnik Berlin GmbH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Stankovic","sequence":"additional","affiliation":[{"name":"LTB Lasertechnik Berlin GmbH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Buder","sequence":"additional","affiliation":[{"name":"Vivantes Klinikum Neuk\u00f6lin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Stuecker","sequence":"additional","affiliation":[{"name":"Ruhr-Univ. Bochum"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Ruhr-Univ. 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Leupold , \u201cOrtsaufgelo\u0308stes Me\u00dfverfahren fu\u0308r die Detektion von Melanin in Fluorophorgemischen einer Festko\u0308rperprobe,\u201d Patentschrift DE 10 2006 029 809 (2006)."},{"key":"10.1117\/1.3155511_r10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1117\/12.728272","volume":"6633","author":"Scholz","year":"2007","journal-title":"Proc. SPIE","ISSN":"https:\/\/id.crossref.org\/issn\/0277-786X","issn-type":"print"},{"key":"10.1117\/1.3155511_r11","doi-asserted-by":"crossref","first-page":"71610X","DOI":"10.1117\/12.808745","volume":"7161","author":"Wei","year":"2009","journal-title":"Proc. SPIE","ISSN":"https:\/\/id.crossref.org\/issn\/0277-786X","issn-type":"print"},{"key":"10.1117\/1.3155511_r12","first-page":"146","volume":"70","author":"Teuchner","year":"1999","journal-title":"Photochem. Photobiol.","ISSN":"https:\/\/id.crossref.org\/issn\/0031-8655","issn-type":"print"},{"key":"10.1117\/1.3155511_r13","unstructured":"A. Ebrahimi , \u201cAufbau einer Me\u00dfeinrichtung zur Untersuchung des nichtlinearen Absorptionsverhaltens von Pigmenten der Haut mittels durchstimmbarer Farbstofflaserimpulse,\u201d thesis, University of Applied Sciences (TFH) Berlin, (2008)."},{"key":"10.1117\/1.3155511_r14","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009453228102"},{"key":"10.1117\/1.3155511_r15","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)75621-X"},{"key":"10.1117\/1.3155511_r16a","doi-asserted-by":"publisher","DOI":"10.1117\/12.453312"},{"key":"10.1117\/1.3155511_r16b","unstructured":"A. Colbert and A. 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