{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:54:19Z","timestamp":1790819659643,"version":"4.1.0"},"reference-count":21,"publisher":"SPIE-Intl Soc Optical Eng","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2009,9,1]]},"abstract":"We present a quantitative near-IR spectroscopy study of the absolute values of oxygen saturation of hemoglobin before and after surgically induced testicular torsion in adult rabbits. Unilateral testicular torsions (0, 540, or 720 deg) on experimental testes and contralateral sham surgery on control testes are performed in four adult rabbits. A specially designed optical probe for measurements at multiple source-detector distances and a commercial frequency-domain tissue spectrometer are used to measure absolute values of testicular hemoglobin saturation. Our results show: (1) a consistent baseline absolute tissue hemoglobin saturation value of 78\u00b15%, (2) a comparable tissue hemoglobin saturation of 77\u00b16% after sham surgery, and (3) a significantly lower tissue hemoglobin saturation of 36\u00b12% after 540- and 720-deg testicular torsion surgery. Our findings demonstrate the feasibility of performing frequency-domain, multidistance near-IR spectroscopy for absolute testicular oximetry in the assessment of testicular torsion. We conclude that near-IR spectroscopy has potential to serve as a clinical diagnostic and monitoring tool for the assessment of absolute testicular hemoglobin desaturation caused by torsion, with the possibility of serving as a complement to conventional color and spectral Doppler ultrasonography.<\/jats:p>","DOI":"10.1117\/1.3253318","type":"journal-article","created":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T18:03:45Z","timestamp":1256753025000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["Noninvasive assessment of testicular torsion in rabbits using frequency-domain near-infrared spectroscopy: prospects for pediatric urology"],"prefix":"10.1117","volume":"14","author":[{"given":"Bertan","family":"Hallacoglu","sequence":"first","affiliation":[{"name":"Tufts Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Matulewicz","sequence":"additional","affiliation":[{"name":"Tufts Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet J.","family":"Paltiel","sequence":"additional","affiliation":[{"name":"Children's Hospital Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Padua","sequence":"additional","affiliation":[{"name":"Children's Hospital Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Gargollo","sequence":"additional","affiliation":[{"name":"Children's Hospital Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Cannon","sequence":"additional","affiliation":[{"name":"Children's Hospital Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Alomari","sequence":"additional","affiliation":[{"name":"Children's Hospital Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Sassaroli","sequence":"additional","affiliation":[{"name":"Tufts Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Fantini","sequence":"additional","affiliation":[{"name":"Tufts Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"10.1117\/1.3253318_r1","doi-asserted-by":"crossref","unstructured":"E. Gratton and S. Fantini , \u201cReflectance and transmittance spectroscopy,\u201d Chap. 11 in\n Lasers and Current Optical Techniques in Biology\n , Comprehensive Series in Photochemistry and Photobiology, Vol. 4, G. Palumbo , R. Pratesi , Eds., pp. 211\u2013258, Royal Chemistry, Cambridge, UK (2004).","DOI":"10.1039\/9781847551207-00211"},{"key":"10.1117\/1.3253318_r2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1997.0055"},{"key":"10.1117\/1.3253318_r3","doi-asserted-by":"publisher","DOI":"10.1117\/12.183988"},{"key":"10.1117\/1.3253318_r4","unstructured":"S. Fantini and M. A. Franceschini , \u201cFrequency-domain techniques for tissue spectroscopy and imaging,\u201d Chap. 7 in\n Handbook of Optical Biomedical Diagnostics\n , V. V. Tuchin , Ed., pp. 405\u2013453, SPIE Press, Bellingham, WA (2002)."},{"key":"10.1117\/1.3253318_r5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630618"},{"key":"10.1117\/1.3253318_r6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1995.tb00672.x"},{"key":"10.1117\/1.3253318_r7","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200204000-00001"},{"key":"10.1117\/1.3253318_r8","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1097\/01.ju.0000138477.85710.69","volume":"172","author":"Kalfa","year":"2004","journal-title":"J. Urol. 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Flannery , \u201cNumerical recipes,\u201d in\n Numerical Recipes in FORTRAN 77\n , 2nd ed.,\n The Art of Scientific Computing\n , Cambridge University Press, Cambridge, U.K. (1992)."},{"key":"10.1117\/1.3253318_r19","doi-asserted-by":"publisher","DOI":"10.1364\/AO.36.004587"},{"key":"10.1117\/1.3253318_r20","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(88)90069-2"},{"key":"10.1117\/1.3253318_r21","doi-asserted-by":"publisher","DOI":"10.1364\/AO.33.005204"}],"container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-14\/issue-05\/054027\/Noninvasive-assessment-of-testicular-torsion-in-rabbits-using-frequency-domain\/10.1117\/1.3253318.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:54:24Z","timestamp":1790816064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-14\/issue-05\/054027\/Noninvasive-assessment-of-testicular-torsion-in-rabbits-using-frequency-domain\/10.1117\/1.3253318.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,1]]},"references-count":21,"journal-issue":{"issue":"05"},"URL":"https:\/\/doi.org\/10.1117\/1.3253318","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,1]]}}}