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Cyanide toxicity was induced in 16 New Zealand white rabbits by intravenous infusion. Animals were divided into three groups: controls (n=5) received saline following cyanide, hydroxocobalamin (N=6) following cyanide, and cobinamide (N=5) following cyanide. Cobinamide caused significantly faster and more complete recovery of oxy- and deoxyhemoglobin concentrations in cyanide-exposed animals than hydroxocobalamin- or saline-treated animals, with a recovery time constant of 13.8\u00b17.1  min compared to 75.4\u00b125.1 and 76.4\u00b142.7  min, for hydroxocobalamin- and saline-treated animals, respectively (p&lt;0.0001). This study indicates that cobinamide more rapidly and completely reverses the physiologic effects of cyanide than equimolar doses of cobalamin at the dose used in this study, and CN effects and response can be followed noninvasively using DOS.<\/jats:p>","DOI":"10.1117\/1.3290816","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T18:06:17Z","timestamp":1263405977000},"page":"1-8","source":"Crossref","is-referenced-by-count":58,"title":["Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring"],"prefix":"10.1117","volume":"15","author":[{"given":"Matthew","family":"Brenner","sequence":"first","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari B.","family":"Mahon","sequence":"additional","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangwoen","family":"Lee","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute and Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-7712","authenticated-orcid":false,"given":"Jae Gwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute and Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Mukai","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute and Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Goodman","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute and Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute and Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ahdout","sequence":"additional","affiliation":[{"name":"Beckman Laser Institute and Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othman","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Univ. of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay S.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Univ. of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Blackledge","sequence":"additional","affiliation":[{"name":"Univ. of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry R.","family":"Boss","sequence":"additional","affiliation":[{"name":"Univ. of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"10.1117\/1.3290816_r1","unstructured":"S. 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