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Changes in mean SHG intensity and intensity ratio take place in early pregnancy, suggesting that submicroscopic changes in collagen fibril size and arrangement occur before macroscopic changes become evident. Fiber size progressively increased from early to late pregnancy, while pores between collagen fibers became larger and farther apart. Analysis of collagen features in premature cervical remodeling show that changes in collagen structure are dissimilar from normal remodeling. The ability to quantify multiple morphological features of collagen that characterize normal cervical remodeling and distinguish abnormal remodeling in preterm birth models supports future studies aimed at development of SHG endoscopic devices for clinical assessment of collagen changes during pregnancy in women and for predicting risk of preterm labor which occurs in 12.5% of all pregnancies.<\/jats:p>","DOI":"10.1117\/1.3381184","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T18:12:58Z","timestamp":1272478378000},"page":"1-10","source":"Crossref","is-referenced-by-count":86,"title":["Second harmonic generation imaging as a potential tool for staging pregnancy and predicting preterm birth"],"prefix":"10.1117","volume":"15","author":[{"given":"Meredith L.","family":"Akins","sequence":"first","affiliation":[{"name":"The Univ. of Texas Southwestern Medical Ctr. at Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Luby-Phelps","sequence":"additional","affiliation":[{"name":"The Univ. of Texas Southwestern Medical Ctr. at Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Mahendroo","sequence":"additional","affiliation":[{"name":"The Univ. of Texas Southwestern Medical Ctr. at Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"10.1117\/1.3381184_r1","unstructured":"Committee on Understanding Premature Birth and Assuring Healthy Outcomes (Ed. 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