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In order to use this technology in clinical practice, the commercial developed device, the CritiView (CRV), is tested in animal models as well as in patients. Methods and Results: The new CRV enables the optical monitoring of four different parameters, representing the energy balance of various tissues in vivo. Mitochondrial NADH is measured by surface fluorometry\/reflectometry. In addition, tissue microcirculatory blood flow, tissue reflectance and oxygenation are measured as well. The device is tested both in vitro and in vivo in a small animal model and in preliminary clinical trials in patients undergoing vascular or open heart surgery. In patients, the monitoring is started immediately after the insertion of a three-way Foley catheter (urine collection) to the patient and is stopped when the patient is discharged from the operating room. The results show that monitoring the urethral wall vitality provides information in correlation to the surgical procedure performed.<\/jats:p>","DOI":"10.1117\/1.3585674","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T18:47:40Z","timestamp":1307990860000},"page":"1-22","source":"Crossref","is-referenced-by-count":30,"title":["Mitochondrial function and tissue vitality: bench-to-bedside real-time optical monitoring system"],"prefix":"10.1117","volume":"16","author":[{"given":"Avraham","family":"Mayevsky","sequence":"first","affiliation":[{"name":"Bar-Ilan Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliyahu","family":"Pewzner","sequence":"additional","affiliation":[{"name":"CritiSense Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Deutsch","sequence":"additional","affiliation":[{"name":"CritiSense Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Walden","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Heldenberg","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Lavee","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salis","family":"Tager","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Kachel","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Raanani","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Preisman","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violete","family":"Glauber","sequence":"additional","affiliation":[{"name":"Sheba Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Segal","sequence":"additional","affiliation":[{"name":"Assuta Medical Ctrs."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"10.1117\/1.3585674_r1","doi-asserted-by":"publisher","DOI":"10.1038\/254056a0"},{"key":"10.1117\/1.3585674_r2","doi-asserted-by":"publisher","DOI":"10.1364\/AO.20.002097"},{"key":"10.1117\/1.3585674_r3","doi-asserted-by":"crossref","unstructured":"A. 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