{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:04:00Z","timestamp":1790622240150,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2013,10,2]]},"abstract":"<jats:p>A versatile, continuous wave, optical parametric oscillator is used in combination with photoacoustic spectroscopy for long-term trace gas experiments of volatile compounds emitted by biological samples. The optical parametric oscillator-based spectrometer (wavelength near 3 \u03bcm, 8-MHz linewidth, output power \u223c1\u2009\u2009W ) is successfully tested for the detection of hydrogen cyanide (HCN) emission from clover leaves, and Pseudomonas bacteria; in addition, the presence of HCN in exhaled human breath is measured. For specific experiments, the spectrometer is operated continuously up to 10 days and has a detection limit of 0.4 parts-per-billion volume of HCN in air over 10 s, using the P8 rotational line in the \u03bd 3   vibrational band of HCN at 3287.25\u2009\u2009cm \u22121  . This results in an overall sensitivity of the system of 2.5\u00d710 \u22129 \u2009\u2009cm \u22121 \u2009Hz \u22121\/2  .<\/jats:p>","DOI":"10.1117\/1.jbo.18.10.107002","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T12:31:21Z","timestamp":1380717081000},"page":"1-9","source":"Crossref","is-referenced-by-count":24,"title":["Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications"],"prefix":"10.1117","volume":"18","author":[{"given":"Denis D.","family":"Arslanov","sequence":"first","affiliation":[{"name":"Radboud Univ. Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Castro","sequence":"additional","affiliation":[{"name":"Univ. Estaudual do Norte Fluminense"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noortje A.","family":"Creemers","sequence":"additional","affiliation":[{"name":"Radboud Univ. Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne H.","family":"Neerincx","sequence":"additional","affiliation":[{"name":"Radboud Univ. Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Spunei","sequence":"additional","affiliation":[{"name":"Radboud Univ. Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mandon","sequence":"additional","affiliation":[{"name":"Radboud Univ. Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona M.","family":"Cristescu","sequence":"additional","affiliation":[{"name":"Radboud Univ. Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Merkus","sequence":"additional","affiliation":[{"name":"Radboud Univ. Nijmegen Medical Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J.","family":"Harren","sequence":"additional","affiliation":[{"name":"Radboud Univ. Nijmegen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-18\/issue-10\/107002\/Optical-parametric-oscillator-based-photoacoustic-detection-of-hydrogen-cyanide-for\/10.1117\/1.JBO.18.10.107002.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:51:56Z","timestamp":1790621516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-18\/issue-10\/107002\/Optical-parametric-oscillator-based-photoacoustic-detection-of-hydrogen-cyanide-for\/10.1117\/1.JBO.18.10.107002.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,2]]},"references-count":0,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.18.10.107002","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,2]]}}}