{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:20Z","timestamp":1792787120920,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"01","funder":[{"name":"National Science Council of Taiwan","award":["NSC 100-2627-E-010-001"],"award-info":[{"award-number":["NSC 100-2627-E-010-001"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Science Council of Taiwan, China","award":["NSC 100-2627-E-010-001"],"award-info":[{"award-number":["NSC 100-2627-E-010-001"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Science Council of Taiwan, China","award":["NSC 99-2314-B-010-029-MY3"],"award-info":[{"award-number":["NSC 99-2314-B-010-029-MY3"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2013,6,20]]},"abstract":"<jats:p>The actin-depolymerizing factor (ADF)\/cofilin protein family has been reported to be associated with ischemia-induced renal disorders. We examine whether cofilin-1 is associated with acute kidney injury (AKI) using human urine samples. We exploited a 96-well based high-throughput biosensor that uses gold nanoparticles and a sandwich immunoassay to detect the urine cofilin-1 level of AKI patients. The mean urine cofilin-1 level of the AKI patients (n=37  from 47 cases analyzed) was twofold higher than that of healthy adults (n=21  from 29 cases analyzed). The receiver operating characteristic (ROC) curve showed that cofilin-1 was acceptable for discriminating AKI patients from healthy adults. However, an increase of the sample size is required to conclude the importance of urine cofilin-1 on AKI diagnosis, and the high-throughput ultrasensitive biosensor used in this study would greatly accelerate the measurement of urine cofilin-1 in an increased sample size.<\/jats:p>","DOI":"10.1117\/1.jbo.19.1.011004","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T12:33:52Z","timestamp":1371731632000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Determination of urine cofilin-1 level in acute kidney injury using a high-throughput localized surface plasmon-coupled fluorescence biosensor"],"prefix":"10.1117","volume":"19","author":[{"given":"Ying-Feng","family":"Chang","sequence":"first","affiliation":[{"name":"Chang Chung Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Han","family":"Chao","sequence":"additional","affiliation":[{"name":"National Taiwan Univ. Hospital, Hsin-Chu Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih-Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"National Tsing Hua Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Han","family":"Tsai","sequence":"additional","affiliation":[{"name":"National Yang-Ming Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien","family":"Chou","sequence":"additional","affiliation":[{"name":"Chang Gung Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-7557","authenticated-orcid":false,"given":"Yi-Jang","family":"Lee","sequence":"additional","affiliation":[{"name":"National Yang-Ming Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-19\/issue-01\/011004\/Determination-of-urine-cofilin-1-level-in-acute-kidney-injury\/10.1117\/1.JBO.19.1.011004.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:27:20Z","timestamp":1790814440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-19\/issue-01\/011004\/Determination-of-urine-cofilin-1-level-in-acute-kidney-injury\/10.1117\/1.JBO.19.1.011004.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2014,1,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.19.1.011004","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]}}}