{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:13:38Z","timestamp":1793729618998,"version":"4.6.1"},"reference-count":44,"publisher":"SPIE-Intl Soc Optical Eng","issue":"08","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIH","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}]},{"name":"National Institutes of Health","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}]},{"name":"National Academies Keck Futures Initiative grant IS 13, and National Institutes of Health","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}]},{"name":"National Institute of Health","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health or Wellcome Trust","award":["DP1 EB016986"],"award-info":[{"award-number":["DP1 EB016986"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIH","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}]},{"name":"National Institutes of Health","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}]},{"name":"NIH Director\u2019s Pioneer Award","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}]},{"name":"(NIH Director\u2019s Pioneer Award)","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}]},{"name":"NIH Director\u2019s Transformative Research Award","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health or Wellcome Trust","award":["R01 CA186567"],"award-info":[{"award-number":["R01 CA186567"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIH","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}]},{"name":"National Institutes of Health grants","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}]},{"name":"NIH Director\u2019s Pioneer Award","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}]},{"name":"National Institute of Health","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}]},{"name":"(NIH Director\u2019s Pioneer Award)","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}]},{"name":"NIH Director\u2019s Transformative Research Award","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA159959"],"award-info":[{"award-number":["R01 CA159959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2014,8,21]]},"abstract":"<jats:p>Complex regional pain syndrome (CRPS) is a chronic pain syndrome that causes intractable pain, disability, and poor quality of life for patients. The etiology and pathophysiology of CRPS are still poorly understood. Due to a lack of proper diagnostic tools, the prognosis of CRPS is primarily based on clinical observation. The objective of this work is to evaluate a new imaging modality, photoacoustic microscopy (PAM), for assisting diagnoses and monitoring the progress and treatment outcome of CRPS. Blood vasculature and oxygen saturation (sO2) were imaged by PAM from eight adult patients with CRPS-1. Patients\u2019 hands and cuticles were imaged both before and after stellate ganglion block (SGB) for comparison. For all patients, both vascular structure and sO2 could be assessed by PAM. In addition, more vessels and stronger signals were observed after SGB. The results show that PAM can help diagnose and monitor CRPS.<\/jats:p>","DOI":"10.1117\/1.jbo.19.8.086017","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T13:10:46Z","timestamp":1408626646000},"page":"1-6","source":"Crossref","is-referenced-by-count":22,"title":["Microcirculatory changes identified by photoacoustic microscopy in patients with complex regional pain syndrome type I after stellate ganglion blocks"],"prefix":"10.1117","volume":"19","author":[{"given":"Yong","family":"Zhou","sequence":"first","affiliation":[{"name":"Washington Univ. in St. Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Yi","sequence":"additional","affiliation":[{"name":"Washington Univ. School of Medicine in St. Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Xing","sequence":"additional","affiliation":[{"name":"Washington Univ. in St. Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-5979","authenticated-orcid":false,"given":"Song","family":"Hu","sequence":"additional","affiliation":[{"name":"Washington Univ. in St. Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin I.","family":"Maslov","sequence":"additional","affiliation":[{"name":"Washington Univ. in St. Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-4383","authenticated-orcid":false,"given":"Lihong V.","family":"Wang","sequence":"additional","affiliation":[{"name":"Washington Univ. in St. Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181e3db38"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1097\/ASA.0b013e31826305ed"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.6.5.669"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b1aa1"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31823da45f"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1159\/000051078"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31822efe30"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.03.054"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.06.021"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn123"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1522-2594"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199802000-00003"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1053\/rapm.2001.21827"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00484-0"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1364\/OL.25.000114"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.3109\/J426v01n04_03"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1038\/nbt839"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1220"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.12.126019"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1063\/1.4803444"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.9.096004"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1364\/OL.38.003882"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.42"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1364\/OL.38.002683"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1216210"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1117\/1.3536522"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.04.030"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1364\/OL.30.000625"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1364\/OL.36.001134"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1364\/OL.38.002592"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2000.00010.x"},{"key":"r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.02.006"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.3.240"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.3.587"},{"key":"r35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08589-6"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.10.035"},{"key":"r37","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00133-Y"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00286-4"},{"key":"r39","doi-asserted-by":"publisher","DOI":"10.1258\/000456303322326524"},{"key":"r40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.08.043"},{"key":"r41","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(86)90157-0"},{"key":"r42","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199104000-00012"},{"key":"r43","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31825adb2b"},{"key":"r44","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.8.080505"}],"container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-19\/issue-08\/086017\/Microcirculatory-changes-identified-by-photoacoustic-microscopy-in-patients-with-complex\/10.1117\/1.JBO.19.8.086017.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:07:46Z","timestamp":1790618866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-19\/issue-08\/086017\/Microcirculatory-changes-identified-by-photoacoustic-microscopy-in-patients-with-complex\/10.1117\/1.JBO.19.8.086017.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,21]]},"references-count":44,"journal-issue":{"issue":"08"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.19.8.086017","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,21]]}}}