{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:22Z","timestamp":1792787122785,"version":"4.5.0"},"reference-count":26,"publisher":"SPIE-Intl Soc Optical Eng","issue":"09","license":[{"start":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T00:00:00Z","timestamp":1411516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation","award":["EXC 1086"],"award-info":[{"award-number":["EXC 1086"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2014,9,24]]},"abstract":"<jats:p>The exact spatial distribution of impaired cerebral autoregulation in carotid artery disease is unknown. In this pilot study, we present a new approach of multichannel near-infrared spectroscopy (mcNIRS) for noninvasive spatial mapping of dynamic autoregulation in carotid artery disease. In 15 patients with unilateral severe carotid artery stenosis or occlusion, cortical hemodynamics in the bilateral frontal cortex were assessed from changes in oxyhemoglobin concentration using 52-channel NIRS (spatial resolution \u223c2\u2009\u2009cm). Dynamic autoregulation was graded by the phase shift between respiratory-induced 0.1\u00a0Hz oscillations of blood pressure and oxyhemoglobin. Ten of 15 patients showed regular phase values in the expected (patho) physiological range. Five patients had clearly outlying irregular phase values mostly due to artifacts. In patients with a regular phase pattern, a significant side-to-side difference of dynamic autoregulation was observed for the cortical border zone area between the middle and anterior cerebral artery (p&lt;0.05). In conclusion, dynamic cerebral autoregulation can be spatially assessed from slow hemodynamic oscillations with mcNIRS. In high-grade carotid artery disease, cortical dynamic autoregulation is affected mostly in the vascular border zone. Spatial mapping of dynamic autoregulation may serve as a powerful tool for identifying brain regions at specific risks for hemodynamic infarction.<\/jats:p>","DOI":"10.1117\/1.jbo.19.9.097005","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T03:30:40Z","timestamp":1411615840000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["Spatial mapping of dynamic cerebral autoregulation by multichannel near-infrared spectroscopy in high-grade carotid artery disease"],"prefix":"10.1117","volume":"19","author":[{"given":"Matthias","family":"Reinhard","sequence":"first","affiliation":[{"name":"Univ. Medical Ctr. Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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