{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:06:16Z","timestamp":1790816776796,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"05","funder":[{"name":"Romanian National Authority for Scientific Research, CNCS-UEFISCDI","award":["PN-II-ID-PCE-2011-3-0922"],"award-info":[{"award-number":["PN-II-ID-PCE-2011-3-0922"]}]},{"name":"Romanian National Authority for Scientific Research, CNCS-UEFISCDI","award":["PN-II-PT-PCCA-2013-3.1-1350"],"award-info":[{"award-number":["PN-II-PT-PCCA-2013-3.1-1350"]}]},{"name":"T. Alexandru was supported by the strategic","award":["POSDRU\/159\/1.5\/S\/137750"],"award-info":[{"award-number":["POSDRU\/159\/1.5\/S\/137750"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2014,11,3]]},"abstract":"<jats:p>The study reports an investigation of the photoproducts obtained by exposure of chlorpromazine hydrochloride in ultrapure water (concentration 2\u2009\u2009mg\/mL) to a 266-nm laser beam obtained by fourth harmonic generation from a Nd:YAG laser (6-ns full time width at half maximum, 10-Hz pulse repetition rate). The photoproducts were analyzed by steady-state UV-Vis absorption, laser-induced fluorescence, Fourier transform infrared spectroscopy, and liquid chromatography\u2013tandem time-of-flight mass spectroscopy. Two figures showing pathways that take place during irradiation for obtaining the final products are shown. The quantum yield of singlet oxygen generation by chlorpromazine (CPZ) was determined relative to standard Zn-phthalocyanine in dimethyl sulfoxide. To outline the role of fluorescence in photoproducts formation rates, fluorescence quantum yield of CPZ during exposure to 355-nm radiation (third harmonic of the fundamental beam of Nd:YAG laser) was investigated relative to standard Coumarin 1 in ethanol. The CPZ solutions exposed 60 and 240\u00a0min to 266-nm laser beam, respectively, were tested against Staphylococcus aureus ATCC 25923 strain. For 25\u2009\u2009\u03bcL of CPZ samples irradiated 240\u00a0min, a higher diameter of inhibition has obtained against the tested strain than for the 60-min exposed ones.<\/jats:p>","DOI":"10.1117\/1.jbo.20.5.051002","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T12:57:53Z","timestamp":1415019473000},"page":"1-11","source":"Crossref","is-referenced-by-count":24,"title":["Characterization of mixtures of compounds produced in chlorpromazine aqueous solutions by ultraviolet laser irradiation: their applications in antimicrobial assays"],"prefix":"10.1117","volume":"20","author":[{"given":"Tatiana","family":"Alexandru","sequence":"first","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Staicu","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru I.","family":"Pascu","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Radu","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development in Chemistry and Petrochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Stoicu","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viorel V.","family":"Nastasa","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra C.","family":"Dinache","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Boni","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Amaral","sequence":"additional","affiliation":[{"name":"Instituto de Higiene e Medicina Tropical UNL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail Lucian","family":"Pascu","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-20\/issue-05\/051002\/Characterization-of-mixtures-of-compounds-produced-in-chlorpromazine-aqueous-solutions\/10.1117\/1.JBO.20.5.051002.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:39:48Z","timestamp":1790815188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-20\/issue-05\/051002\/Characterization-of-mixtures-of-compounds-produced-in-chlorpromazine-aqueous-solutions\/10.1117\/1.JBO.20.5.051002.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,3]]},"references-count":0,"journal-issue":{"issue":"05"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.20.5.051002","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,3]]}}}