{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:24Z","timestamp":1792787124620,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"05","funder":[{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AFOSR","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}],"id":[{"id":"https:\/\/ror.org\/011e9bt93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Military Photomedicine Program","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}]},{"name":"Military Photomedicine Program, AFOSR","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}]},{"name":"National Institute of Environmental Health Sciences","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}],"id":[{"id":"https:\/\/ror.org\/00j4k1h63","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Military Medical Photonics Program, AFOSR","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}]},{"name":"NSF IGERT","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}]},{"name":"Air Force Office of Scientific Research Medical Free-Electron Laser Program","award":["FA9550-08-1-0384"],"award-info":[{"award-number":["FA9550-08-1-0384"]}]},{"name":"National Institutes of Health, National Institute of Neurological Diseases and Stroke","award":["U01 NS058030"],"award-info":[{"award-number":["U01 NS058030"]}]},{"name":"NIAMS","award":["F32 AR065356-01A1"],"award-info":[{"award-number":["F32 AR065356-01A1"]}],"id":[{"id":"https:\/\/ror.org\/006zn3t30","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2015,1,6]]},"abstract":"<jats:p>Low level light therapy (LLLT) has numerous therapeutic benefits, including improving wound healing, but the precise mechanisms involved are not well established; in particular, the underlying role of cytochrome C oxidase (C-ox) as the primary photoacceptor and the associated biochemical mechanisms still require further investigation. We previously showed the nitric oxide (NO) donating drug nitrosyl-cobinamide (NO-Cbi) enhances wound healing through a cGMP\/cGMP-dependent protein kinase\/ERK1\/2 mechanism. Here, we show that the combination of LLLT and NO-Cbi markedly improves wound healing compared to either treatment alone. LLLT-enhanced wound healing proceeded through an electron transport chain-C-ox-dependent mechanism with a reduction of reactive oxygen species and increased adenosine triphosphate production. C-ox was validated as the primary photoacceptor by three observations: increased oxygen consumption, reduced wound healing in the presence of sodium azide, and disassociation of cyanide, a known C-ox ligand, following LLLT. We conclude that LLLT and NO-Cbi accelerate wound healing through two independent mechanisms, the electron transport chain-C-ox pathway and cGMP signaling, respectively, with both resulting in ERK1\/2 activation.<\/jats:p>","DOI":"10.1117\/1.jbo.20.5.051022","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T12:30:15Z","timestamp":1420547415000},"page":"1-8","source":"Crossref","is-referenced-by-count":17,"title":["Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing"],"prefix":"10.1117","volume":"20","author":[{"given":"Ryan","family":"Spitler","sequence":"first","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang","family":"Ho","sequence":"additional","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Norpetlian","sequence":"additional","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangduo","family":"Kong","sequence":"additional","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Univ. of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Yokomori","sequence":"additional","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogi","family":"Andersen","sequence":"additional","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry R.","family":"Boss","sequence":"additional","affiliation":[{"name":"Univ. of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Berns","sequence":"additional","affiliation":[{"name":"Univ. of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-20\/issue-05\/051022\/Combination-of-low-level-light-therapy-and-nitrosyl-cobinamide-accelerates\/10.1117\/1.JBO.20.5.051022.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:39:56Z","timestamp":1790815196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-20\/issue-05\/051022\/Combination-of-low-level-light-therapy-and-nitrosyl-cobinamide-accelerates\/10.1117\/1.JBO.20.5.051022.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,6]]},"references-count":0,"journal-issue":{"issue":"05"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.20.5.051022","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,6]]}}}