{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:04:16Z","timestamp":1790816656885,"version":"4.1.0"},"reference-count":19,"publisher":"SPIE-Intl Soc Optical Eng","issue":"01","funder":[{"name":"NIH","award":["5SC1HD068129 (ARC)"],"award-info":[{"award-number":["5SC1HD068129 (ARC)"]}]},{"name":"NIH","award":["2G12RR003060-26A1"],"award-info":[{"award-number":["2G12RR003060-26A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2016,1,27]]},"abstract":"<jats:p>The terahertz (THz) absorption and index of refraction of brain tissues from a mouse model of Alzheimer\u2019s disease (AD) and a control wild-type (normal) mouse were compared using THz time-domain spectroscopy (THz-TDS). Three dominating absorption peaks associated to torsional\u2013vibrational modes were observed in AD tissue, at about 1.44, 1.8, and 2.114\u00a0THz, closer to the peaks of free tryptophan molecules than in normal tissue. A possible reason is that there is more free tryptophan in AD brain tissue, while in normal brain tissue more tryptophan is attached to other molecules. Our study suggests that THz-absorption modes may be used as an AD biomarker fingerprint in brain, and that THz-TDS is a promising technique for early diagnosis of AD.<\/jats:p>","DOI":"10.1117\/1.jbo.21.1.015014","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T21:32:54Z","timestamp":1453930374000},"page":"1-5","source":"Crossref","is-referenced-by-count":33,"title":["Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer\u2019s disease"],"prefix":"10.1117","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1373-3206","authenticated-orcid":false,"given":"Lingyan","family":"Shi","sequence":"first","affiliation":[{"name":"The City College of New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Shumyatsky","sequence":"additional","affiliation":[{"name":"The City College of New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Rodr\u00edguez-Contreras","sequence":"additional","affiliation":[{"name":"The City College of New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Alfano","sequence":"additional","affiliation":[{"name":"The City College of New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.06.004"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1433"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.638"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702006906"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050029"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1126\/science.155.3759.217"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1366\/13-07165"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.113647"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(04)74233-2"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4188-13.2014"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00434-3"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20990"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.058172"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1021\/cr020685g"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1117\/1.3554742"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.5.002837"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.7.077001"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1049\/el.2009.3413"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.020631"}],"container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-21\/issue-01\/015014\/Terahertz-spectroscopy-of-brain-tissue-from-a-mouse-model-of\/10.1117\/1.JBO.21.1.015014.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:30:01Z","timestamp":1790814601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-21\/issue-01\/015014\/Terahertz-spectroscopy-of-brain-tissue-from-a-mouse-model-of\/10.1117\/1.JBO.21.1.015014.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,27]]},"references-count":19,"journal-issue":{"issue":"01"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.21.1.015014","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,27]]}}}