{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:59:36Z","timestamp":1790301576504,"version":"4.1.0"},"reference-count":50,"publisher":"SPIE-Intl Soc Optical Eng","issue":"10","funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL124417"],"award-info":[{"award-number":["R01 HL124417"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2017,10,27]]},"abstract":"<jats:p>Coronary heart disease (the presence of coronary atherosclerotic plaques) is a significant health problem in the industrialized world. A clinical method to accurately visualize and characterize atherosclerotic plaques is needed. Intravascular photoacoustic (IVPA) imaging is being developed to fill this role, but questions remain regarding optimal imaging wavelengths. We utilized a Monte Carlo optical model to simulate IVPA excitation in coronary tissues, identifying optimal wavelengths for plaque characterization. Near-infrared wavelengths (\u22641800\u2009\u2009nm) were simulated, and single- and dual-wavelength data were analyzed for accuracy of plaque characterization. Results indicate light penetration is best in the range of 1050 to 1370\u00a0nm, where 5% residual fluence can be achieved at clinically relevant depths of \u22652\u2009\u2009mm in arteries. Across the arterial wall, fluence may vary by over 10-fold, confounding plaque characterization. For single-wavelength results, plaque segmentation accuracy peaked at 1210 and 1720\u00a0nm, though correlation was poor (&lt;0.13). Dual-wavelength analysis proved promising, with 1210\u00a0nm as the most successful primary wavelength (\u22481.0). Results suggest that, without flushing the luminal blood, a primary and secondary wavelength near 1210 and 1350\u00a0nm, respectively, may offer the best implementation of dual-wavelength IVPA imaging. These findings could guide the development of a cost-effective clinical system by highlighting optimal wavelengths and improving plaque characterization.<\/jats:p>","DOI":"10.1117\/1.jbo.22.10.106012","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T21:22:19Z","timestamp":1509052939000},"page":"1-12","source":"Crossref","is-referenced-by-count":8,"title":["Optimization of dual-wavelength intravascular photoacoustic imaging of atherosclerotic plaques using Monte Carlo optical modeling"],"prefix":"10.1117","volume":"22","author":[{"given":"Nicholas","family":"Dana","sequence":"first","affiliation":[{"name":"The Univ. of Texas at Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9293-0472","authenticated-orcid":false,"given":"Timothy","family":"Sowers","sequence":"additional","affiliation":[{"name":"Georgia Institute of 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