{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:02:40Z","timestamp":1790377360696,"version":"4.1.0"},"reference-count":24,"publisher":"SPIE-Intl Soc Optical Eng","issue":"05","funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2017,5,13]]},"abstract":"<jats:p>Bisphosphonates (BPs) are being increasingly used for the treatment of metabolic and oncological pathologies involving the skeletal system. Because of the severity of the BP associated osteonecrosis of the jaws, the difficulties of treatment, and patient discomfort, additional support methods for their management are needed. Laser therapy has an easy handling, photobiostimulator effect on tissues healing, so it can be considered a preferred therapy. The aim of this study was to evaluate the influence of low-level laser therapy in the 685- and 830-nm wavelength in the healing process of the bone and soft tissues in rats under BP therapy [zoledronic acid (ZA)] and dexamethasone concomitantly that underwent a surgery for the extraction of upper molars. There were statistically significant differences in the clinical evaluation of the wound and the weight of the animals. Regarding the histological evaluation, it was possible to observe the different maturations of the healing stage between groups. The effect of drug therapy with ZA and dexamethasone in the bone tissue repair process induces osteonecrosis of the jaw in rats and slows down the healing process. In the laser groups, at the stipulated dosimetry, a positive influence on the bone and soft tissue repair process was observed.<\/jats:p>","DOI":"10.1117\/1.jbo.22.5.058001","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T12:30:57Z","timestamp":1494678657000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Effect of low-level laser therapy on tissue repair after dental extraction in rats administered zoledronic acid and dexamethasone"],"prefix":"10.1117","volume":"22","author":[{"given":"Jo\u00e3o Batista Blessmann","family":"Weber","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Univ. Cat\u00f3lica do Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Stifelman","family":"Camilotti","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Univ. Cat\u00f3lica do Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Jasper","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Univ. Cat\u00f3lica do Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane Cristina Onofre","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Univ. Cat\u00f3lica do Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Luiz Dal Moro","family":"Maito","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Univ. Cat\u00f3lica do Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0929-7"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3219"},{"key":"r3","first-page":"25","article-title":"Bisfosfonatos e osteonecrose maxilar: revis\u00e3o da literatura e relato de dois casos","author":"Gegler","year":"2006"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.4065\/83.9.1032"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0816-7"},{"key":"r6","first-page":"287","article-title":"Les\u00f5es f\u00edsicas e qu\u00edmicas","author":"Nevile","year":"2009"},{"key":"r7","first-page":"235","article-title":"Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates","author":"Dunford","year":"2001"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0654-7"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2501"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.03.016"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(08)01667-4"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2181"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00009"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/672027"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0568-9"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.04.013"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1068-5"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4332(99)00431-6"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1111\/jor.2006.33.issue-8"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020150030000007"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00294-9"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(94)07078-3"}],"container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-22\/issue-05\/058001\/Effect-of-low-level-laser-therapy-on-tissue-repair-after\/10.1117\/1.JBO.22.5.058001.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:56:35Z","timestamp":1790376995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-22\/issue-05\/058001\/Effect-of-low-level-laser-therapy-on-tissue-repair-after\/10.1117\/1.JBO.22.5.058001.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,13]]},"references-count":24,"journal-issue":{"issue":"05"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.22.5.058001","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,13]]}}}