{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:30:20Z","timestamp":1794411020584,"version":"4.9.0"},"reference-count":55,"publisher":"SPIE-Intl Soc Optical Eng","issue":"10","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ontario Student Assistance Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2018,10,12]]},"abstract":"<jats:p>Radiation therapy (RT) is widely and effectively used for cancer treatment but can also cause deleterious side effects, such as a late-toxicity complication called radiation-induced fibrosis (RIF). Accurate diagnosis of RIF requires analysis of histological sections to assess extracellular matrix infiltration. This is invasive, prone to sampling limitations, and thus rarely used; instead, current practice relies on subjective clinical surrogates, including visual observation, palpation, and patient symptomatology questionnaires. This preclinical study demonstrates that functional optical coherence tomography (OCT) is a useful tool for objective noninvasive in-vivo assessment and quantification of fibrosis-associated microvascular changes in tissue. Data were collected from murine hind limbs 6 months after 40-Gy single-dose irradiation and compared with nonirradiated contralateral tissues of the same animals. OCT-derived vascular density and average vessel diameter metrics were compared to quantitative vascular analysis of stained histological slides. Results indicate that RIF manifests significant microvascular changes at this time point posttreatment. Abnormal microvascular changes visualized by OCT in this preclinical setting suggest the potential of this label-free high-resolution noninvasive functional imaging methodology for RIF diagnosis and assessment in the context of clinical RT.<\/jats:p>","DOI":"10.1117\/1.jbo.23.10.106003","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T08:37:00Z","timestamp":1539333420000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography"],"prefix":"10.1117","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-3858","authenticated-orcid":false,"given":"Valentin","family":"Demidov","sequence":"first","affiliation":[{"name":"Univ. of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Univ. of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Demidova","sequence":"additional","affiliation":[{"name":"Seneca College of Applied Arts and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary Y. M.","family":"Pang","sequence":"additional","affiliation":[{"name":"Univ. of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costel","family":"Flueraru","sequence":"additional","affiliation":[{"name":"National Research Council Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Univ. of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Alex","family":"Vitkin","sequence":"additional","affiliation":[{"name":"Univ. of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00036-5"},{"key":"r2","first-page":"99","article-title":"Radiobiology of normal tissues","author":"Van der Kogel","year":"1993"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00037-7"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.09.014"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00419-L"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.12.013"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-015-1974-6"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.020"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00741-4"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00183-2"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.032"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2003.00357.x"},{"key":"r13","author":"Cognetta","year":"2013"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00423-I"},{"key":"r15","first-page":"147","article-title":"Integumentary system dose response of the epidermal, microvascular, and dermal populations","author":"Archambeau","year":"1987"},{"key":"r16","article-title":"The ratio for nonhealing in swine skin: an estimate of microvessel endothelial dose tolerance","author":"Archambeau","year":"1993"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90318-5"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.2307\/3573365"},{"key":"r19","first-page":"859","article-title":"The effect of ionizing radiation on capillary sprouting and remodeling in the regenerating blastema observed in the rabbit ear chamber","author":"Van Den Brenk","year":"1959"},{"key":"r20","author":"White","year":"1975"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.2147\/CCID"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/20164607"},{"key":"r23","first-page":"34","article-title":"Radiation-induced breast telangiectasias treated with the pulsed dye laser","author":"Rossi","year":"2014"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1321-1"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.2010.24.issue-8"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-006-0416-8"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957169"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2000.006001006.x"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.6.061224"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1152-x"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1417-7"},{"key":"r32","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202682"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1117\/1.1645797"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.1364\/OL.33.001530"},{"key":"r35","doi-asserted-by":"publisher","DOI":"10.1118\/1.3533947"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-3-40"},{"key":"r37","doi-asserted-by":"publisher","DOI":"10.1667\/RR3237.1"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1109\/TIM.2011.2126950"},{"key":"r39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18635-w"},{"key":"r40","doi-asserted-by":"publisher","DOI":"10.1364\/OL.35.001257"},{"key":"r41","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.7.076014"},{"key":"r42","author":"Fitzpatrick","year":"2000"},{"key":"r43","doi-asserted-by":"publisher","DOI":"10.1109\/TSMC.1979.4310076"},{"key":"r44","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-10-r100"},{"key":"r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.09.008"},{"key":"r46","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.6.061213"},{"key":"r47","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00423-I"},{"key":"r48","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70014-1"},{"key":"r49","author":"Panizzon","year":"2015"},{"key":"r50","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.004551"},{"key":"r51","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.2001.0651"},{"key":"r52","doi-asserted-by":"publisher","DOI":"10.1515\/plm-2015-0025"},{"key":"r53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16823-2"},{"key":"r54","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201700292"},{"key":"r55","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.8.081210"}],"container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-23\/issue-10\/106003\/Preclinical-quantitative-in-vivo-assessment-of-skin-tissue-vascularity-in\/10.1117\/1.JBO.23.10.106003.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:29:43Z","timestamp":1790296183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-23\/issue-10\/106003\/Preclinical-quantitative-in-vivo-assessment-of-skin-tissue-vascularity-in\/10.1117\/1.JBO.23.10.106003.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,12]]},"references-count":55,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.23.10.106003","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,12]]}}}