{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:01:53Z","timestamp":1790298113780,"version":"4.1.0"},"reference-count":66,"publisher":"SPIE-Intl Soc Optical Eng","issue":"09","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nazarbayev University","award":["SST0142015"],"award-info":[{"award-number":["SST0142015"]}],"id":[{"id":"https:\/\/ror.org\/052bx8q98","id-type":"ROR","asserted-by":"publisher"}]},{"name":"MES RK","award":["BR05236454"],"award-info":[{"award-number":["BR05236454"]}]},{"name":"MES RK","award":["13 No. 0121-1"],"award-info":[{"award-number":["13 No. 0121-1"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1455671"],"award-info":[{"award-number":["1455671"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1532188"],"award-info":[{"award-number":["1532188"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1509268"],"award-info":[{"award-number":["1509268"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01GM127696"],"award-info":[{"award-number":["1R01GM127696"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health (NIH) or Welcome Trust","award":["1R01GM127696"],"award-info":[{"award-number":["1R01GM127696"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2018,9,27]]},"abstract":"<jats:p>Biomechanical properties of mammalian bones, such as strength, toughness, and plasticity, are essential for understanding how microscopic-scale mechanical features can link to macroscale bones\u2019 strength and fracture resistance. We employ Brillouin light scattering (BLS) microspectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins, and osteogenic stem cells in the regeneration of the bone tissues. BLS is noninvasive and label-free modality for probing viscoelastic properties of tissues that can give information on structure-function properties of normal and pathological tissues. Results showed that MCS and BPMs are critically important for regeneration of elastic and viscous properties, respectively, HCF gels containing combination of all factors had the best effect with complete defect regeneration at week nine after the implantation of bone grafts and that the bones with fully consolidated fractures have higher values of elastic moduli compared with defective bones.<\/jats:p>","DOI":"10.1117\/1.jbo.23.9.097004","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T09:50:59Z","timestamp":1538041859000},"page":"1-11","source":"Crossref","is-referenced-by-count":37,"title":["Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones"],"prefix":"10.1117","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-0355","authenticated-orcid":false,"given":"Dana","family":"Akilbekova","sequence":"first","affiliation":[{"name":"Nazarbayev Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyacheslav","family":"Ogay","sequence":"additional","affiliation":[{"name":"National Ctr. for Biotechnology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talgat","family":"Yakupov","sequence":"additional","affiliation":[{"name":"Nazarbayev Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madina","family":"Sarsenova","sequence":"additional","affiliation":[{"name":"National Ctr. for Biotechnology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bauyrzhan","family":"Umbayev","sequence":"additional","affiliation":[{"name":"Nazarbayev Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asset","family":"Nurakhmetov","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Traumatology and Orthopedics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairat","family":"Tazhin","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Traumatology and Orthopedics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-1013","authenticated-orcid":false,"given":"Vladislav V.","family":"Yakovlev","sequence":"additional","affiliation":[{"name":"Texas A&M Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhandos N.","family":"Utegulov","sequence":"additional","affiliation":[{"name":"Nazarbayev Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-013-0137-0"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-014-5240-2"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1038\/79449"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.228"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2017.59"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4312-z"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.08.002"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1210"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513506445"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.07.014"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04175.x"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2009.0390"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.07.028"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.3.1740237"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-4533(98)00007-1"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf6326"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.0739"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1364\/AOP.8.000300"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1364\/OE.26.002400"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/45\/3\/002"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1121\/1.4862883"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1038\/srep18139"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.009197"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1038\/267285a0"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1038\/284489a0"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.397"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.388"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1039\/c3an02168h"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b02104"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1101\/181560"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2012.09.026"},{"key":"r32","doi-asserted-by":"publisher","DOI":"10.1115\/1.4003131"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.48.07GK01"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.51.07GF20"},{"key":"r35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultras.2013.09.016"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/59\/6\/1389"},{"key":"r37","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.47.4205"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/38\/384003"},{"key":"r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.01.072"},{"key":"r40","doi-asserted-by":"publisher","DOI":"10.1117\/12.2080334"},{"key":"r41","doi-asserted-by":"publisher","DOI":"10.1063\/1.3377905"},{"key":"r42","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.001366"},{"key":"r43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2008.11.008"},{"key":"r44","doi-asserted-by":"publisher","DOI":"10.1117\/12.2289923"},{"key":"r45","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00160"},{"key":"r46","first-page":"440","article-title":"Bone, its mineral and bone diseases","author":"Driessens","year":"1990"},{"key":"r47","doi-asserted-by":"publisher","DOI":"10.1063\/1.447892"},{"key":"r48","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/17\/003"},{"key":"r49","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.2.5751"},{"key":"r50","doi-asserted-by":"publisher","DOI":"10.1017\/S0021878298003744"},{"key":"r51","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.040"},{"key":"r52","doi-asserted-by":"publisher","DOI":"10.1038\/lsa.2017.139"},{"key":"r53","first-page":"2508","article-title":"Relationship between elastic modulus and viscosity of bone matrix is strong independent of species, anatomical sites, and types of bone","author":"Sarandeep","year":"2008"},{"key":"r54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.08.017"},{"key":"r55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00651.x"},{"key":"r56","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-016-0809-y"},{"key":"r57","doi-asserted-by":"publisher","DOI":"10.1021\/bm5003416"},{"key":"r58","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(03)00113-1"},{"key":"r59","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2006.05.056"},{"key":"r60","doi-asserted-by":"publisher","DOI":"10.1115\/1.4000936"},{"key":"r61","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(93)90615-L"},{"key":"r62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2008.09.019"},{"key":"r63","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31817151b0"},{"key":"r64","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00221-7"},{"key":"r65","doi-asserted-by":"publisher","DOI":"10.1038\/srep35398"},{"key":"r66","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2013.2643"}],"container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-23\/issue-09\/097004\/Brillouin-spectroscopy-and-radiography-for-assessment-of-viscoelastic-and-regenerative\/10.1117\/1.JBO.23.9.097004.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:31:28Z","timestamp":1790296288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-23\/issue-09\/097004\/Brillouin-spectroscopy-and-radiography-for-assessment-of-viscoelastic-and-regenerative\/10.1117\/1.JBO.23.9.097004.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":66,"journal-issue":{"issue":"09"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.23.9.097004","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]}}}