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We noted small but statistically significant differences in thickness measurements of the mucosa and submucosa layers in the larynx (&lt;italic&gt;p&lt;\/italic&gt;\u2009\u2009&amp;lt;\u2009\u20090.001), subglottis (&lt;italic&gt;p&lt;\/italic&gt;\u2009\u2009=\u2009\u20090.015), and trachea (&lt;italic&gt;p&lt;\/italic&gt;\u2009\u2009=\u2009\u20090.012). The automated algorithm was also shown to be over 8 times faster than the manual approach. Moderate Pearson correlations were found between different tissue texture parameters and the patient\u2019s gestational age at birth, age in days, duration of intubation, and differences with age (mean age 17 days). 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