{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:36:18Z","timestamp":1793871378226,"version":"4.6.1"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"02","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2021,2,10]]},"abstract":"<jats:p>Significance: While spectral-domain optical coherence tomography (SD-OCT) is a preferred form of OCT imaging, sensitivity roll-off limits its applicability for certain biomedical imaging applications.\nAim: The aim of this work is to extend the imaging range of conventional SD-OCT systems for imaging large luminal organs such as the gastrointestinal tract.\nApproach: We present an SD-OCT system operating at a center wavelength of 1300\u00a0nm that uses two delayed reference arms to reduce sensitivity roll-off and an optical switch and a fiber optic delay line to ensure that the interference spectra are acquired from the same sample time window.\nResult: The proposed system was used to image swine colon ex vivo and duodenum in vivo, demonstrating improved image quality due to a \u223c14\u2009\u2009dB increase in sensitivity at the edges of the ranging depth.\nConclusion: The proposed system requires modest hardware implementation and is compatible with catheter-based endoscopic helical scanning with enhanced sensitivity for the samples at a distance of \u223c6\u2009\u2009mm from the zero delay point.<\/jats:p>","DOI":"10.1117\/1.jbo.26.2.025001","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T08:59:32Z","timestamp":1612947572000},"page":"1-12","source":"Crossref","is-referenced-by-count":3,"title":["Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography"],"prefix":"10.1117","volume":"26","author":[{"given":"David O.","family":"Otuya","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Verma","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Luu","sequence":"additional","affiliation":[{"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1892-0265","authenticated-orcid":false,"given":"Hamid","family":"Farrokhi","sequence":"additional","affiliation":[{"name":"Wellman Ctr. for Photomedicine, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo J.","family":"Tearney","sequence":"additional","affiliation":[{"name":"Wellman Ctr. for Photomedicine, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-26\/issue-02\/025001\/Improved-sensitivity-roll-off-in-dual-reference-buffered-spectral-domain\/10.1117\/1.JBO.26.2.025001.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:41:55Z","timestamp":1790271715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-26\/issue-02\/025001\/Improved-sensitivity-roll-off-in-dual-reference-buffered-spectral-domain\/10.1117\/1.JBO.26.2.025001.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":0,"journal-issue":{"issue":"02"},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.26.2.025001","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]}}}