{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:03:23Z","timestamp":1790215403138,"version":"4.1.0"},"reference-count":34,"publisher":"SPIE-Intl Soc Optical Eng","issue":"12","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2022,12,24]]},"abstract":"<jats:p>SignificanceDue to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention.AimWe aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention.ApproachThe DVOS used near-infrared light (670 &lt; \u03bb &lt; 850 nm) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible.ResultsThe total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size (N = 9) and patients with ulcers that did not (N = 5) 3 to 4 weeks after intervention (p\u2009value &lt; 0.001). Data correlated strongly (89% sensitivity, 100% specificity, and AUC = 0.96) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing.ConclusionsThis pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention.<\/jats:p>","DOI":"10.1117\/1.jbo.27.12.125002","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T10:24:36Z","timestamp":1671877476000},"page":"1-14","source":"Crossref","is-referenced-by-count":6,"title":["Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy"],"prefix":"10.1117","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3785-9583","authenticated-orcid":false,"given":"Nisha","family":"Maheshwari","sequence":"first","affiliation":[{"name":"New York Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Marone","sequence":"additional","affiliation":[{"name":"New York Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Alto\u00e9","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Ctr."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H. 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