{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:15:24Z","timestamp":1790270124955,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"05","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2022,5,13]]},"abstract":"<jats:p>Significance: Optical polarimetry is an emerging modality that effectively quantifies the bulk optical properties that correlate with the anisotropic structural properties of cardiac tissues. We demonstrate the application of a polarimetric tool for characterizing healthy and fibrotic human myocardial tissues efficiently with a high degree of accuracy.\nAim: The study was aimed to characterize the myocardial tissues from the left ventricle and right ventricle of N\u2009\u2009=\u2009\u20097 control and N\u2009\u2009=\u2009\u200910 diseased subjects. The diseased subjects were composed of two groups: N\u2009\u2009=\u2009\u20097 with rheumatic heart disease (RHD) and N\u2009\u2009=\u2009\u20093 with myxomatous valve (MV) disease.\nApproach: A portable, affordable, and accurate linear polarization-based diagnostic tool is developed to measure the degree of linear polarization (DOLP) of the myocardial tissues while working at a wavelength of 850\u00a0nm.\nResults: The sensitivity, specificity, and accuracy of the polarimetric tool in distinguishing the control group from the RHD group were found to be 73.33%, 76.92%, and 75%, respectively, and from the MV group were 91.6%, 62.5%, and 80%, respectively, which demonstrates the efficacy of the polarimetric tool to distinguish the healthy myocardial tissues from diseased tissues.\nConclusions: We have successfully developed a polarimetric tool that can aid cardiologists in characterizing the myocardial tissues in conjunction with endomyocardial biopsy. This work should be followed up with experiments on a large cohort of control and diseased subjects. We intend to create and develop a probe to quantify the DOLP of in vivo heart tissue during surgery.<\/jats:p>","DOI":"10.1117\/1.jbo.27.5.055001","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T13:30:35Z","timestamp":1652448635000},"page":"1-13","source":"Crossref","is-referenced-by-count":4,"title":["Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium"],"prefix":"10.1117","volume":"27","author":[{"given":"Twinkle","family":"Bagha","sequence":"first","affiliation":[{"name":"Indian Institute of Science, Bengaluru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif Mohd","family":"Kamal","sequence":"additional","affiliation":[{"name":"Indian Institute of Science, Bengaluru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3597-3043","authenticated-orcid":false,"given":"Uttam M.","family":"Pal","sequence":"additional","affiliation":[{"name":"Indian Institute of Science, Bengaluru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna Simha","family":"Mohan Rao","sequence":"additional","affiliation":[{"name":"Sri Jayadeva Institute of Cardiovascular Sciences and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-8323","authenticated-orcid":false,"given":"Hardik J.","family":"Pandya","sequence":"additional","affiliation":[{"name":"Indian Institute of Science, Bengaluru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-27\/issue-05\/055001\/Toward-the-development-of-a-polarimetric-tool-to-diagnose-the\/10.1117\/1.JBO.27.5.055001.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:50:19Z","timestamp":1790268619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-27\/issue-05\/055001\/Toward-the-development-of-a-polarimetric-tool-to-diagnose-the\/10.1117\/1.JBO.27.5.055001.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,13]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2022,5,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.27.5.055001","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,13]]}}}