{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:11:42Z","timestamp":1792249902411,"version":"4.4.0"},"reference-count":31,"publisher":"SPIE-Intl Soc Optical Eng","issue":"07","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2022,7,11]]},"abstract":"<jats:p>Significance: Light is a good probe for studying the nanoscale-level structural or molecular-specific structural properties of brain cells\/tissue due to stress, alcohol, or any other abnormalities. Chronic alcoholism during pregnancy, i.e., fetal alcoholism, being teratogenic, results in fetal alcohol syndrome, and other neurological disorders. Understanding the nano-to-submicron scale spatial structural properties of pup brain cells\/tissues using light\/photonic probes could provide a plethora of information in understanding the effects of fetal alcoholism.\nAim: Using both light scattering and light localization techniques to probe alterations in nano- to-submicron scale mass density or refractive index fluctuations in brain cells\/tissues of mice pups, exposed to fetal alcoholism.\nApproach: We use the mesoscopic physics-based dual spectroscopic imaging techniques, partial wave spectroscopy (PWS) and molecular-specific inverse participation ratio (IPR) using confocal imaging, to quantify structural alterations in brain tissues and chromatin\/histone in brain cells, respectively, in 60 days postnatal mice pup brain, exposed to fetal alcoholism.\nResults: The finer focusing PWS analysis on tissues shows an increase in the degree of structural disorder strength in the pup brain tissues. Furthermore, results of the molecular-specific light localization IPR technique show an increase in the degree of spatial molecular mass density structural disorder in DNA and a decrease in the degree in histone.\nConclusions: In particular, we characterize the spatial pup brain structures from the molecular to tissue levels and address the plausible reasons for such as mass density fluctuations in fetal alcoholism.<\/jats:p>","DOI":"10.1117\/1.jbo.27.7.076002","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:50:35Z","timestamp":1657500635000},"page":"1-12","source":"Crossref","is-referenced-by-count":3,"title":["Photonics probing of pup brain tissue and molecular-specific nuclear nanostructure alterations due to fetal alcoholism via light scattering\/localization approaches"],"prefix":"10.1117","volume":"27","author":[{"given":"Prakash","family":"Adhikari","sequence":"first","affiliation":[{"name":"Mississippi State 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