{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:21:44Z","timestamp":1792398104559,"version":"4.4.0"},"reference-count":27,"publisher":"SPIE-Intl Soc Optical Eng","issue":"08","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2022,8,13]]},"abstract":"<jats:p>Significance: Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced high-resolution imaging modality based on a combination of low-coherence optical interferometry and reflectance confocal optical microscopy with line illumination and line detection. Capable of producing three-dimensional (3D) images of the skin with cellular resolution, in vivo, LC-OCT has been mainly applied in dermatology and dermo-cosmetology. The LC-OCT devices capable of acquiring 3D images reported so far are based on a Linnik interferometer using two identical microscope objectives. In this configuration, LC-OCT cannot be designed to be a very compact and light device, and the image acquisition speed is limited.Aim: The objective of this work was to develop a more compact and lighter LC-OCT device that is capable of acquiring images faster without significant degradation of the resolution and with optimized detection sensitivity.Approach: We developed an LC-OCT device based on a Mirau interferometer using a single objective. Dynamic adjustment of the camera frequency during the depth scan is implemented, using a faster camera and a more powerful light source. The reflectivity of the beam-splitter in the Mirau interferometer was optimized to maximize the detection sensitivity. A galvanometer scanner was incorporated into the device for scanning the illumination line laterally. A stack of adjacent B-scans, constituting a 3D image, can thus be acquired.Results: The device is able to acquire and display B-scans at 17\u00a0fps. 3D images with a quasi-isotropic resolution of \u223c1.5 \u03bcm (1.3, 1.9, and 1.1 \u03bcm in the x , y, and z directions, respectively) over a field of 940 \u03bcm \u00d7 600 \u03bcm \u00d7 350 \u03bcm (x \u00d7 y \u00d7 z) can be obtained. 3D imaging of human skin at cellular resolution, in vivo, is reported.Conclusions: The acquisition rate of the B-scans, at 17 fps, is unprecedented in LC-OCT. Compared with the conventional LC-OCT devices based on a Linnik interferometer, the reported Mirau-based LC-OCT device can acquire B-scans \u223c2 times faster. With potential advantages in terms of compactness and weight, a Mirau-based device could easily be integrated into a smaller and lighter handheld probe for use by dermatologists in their daily medical practice.<\/jats:p>","DOI":"10.1117\/1.jbo.27.8.086002","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T21:38:30Z","timestamp":1660340310000},"page":"1-13","source":"Crossref","is-referenced-by-count":8,"title":["Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging"],"prefix":"10.1117","volume":"27","author":[{"given":"Weikai","family":"Xue","sequence":"first","affiliation":[{"name":"Univ. Paris-Saclay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Ogien","sequence":"additional","affiliation":[{"name":"DAMAE Medical"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel V.","family":"Bulkin","sequence":"additional","affiliation":[{"name":"Ecole Polytechnique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"Coutrot","sequence":"additional","affiliation":[{"name":"Univ. Paris-Saclay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Dubois","sequence":"additional","affiliation":[{"name":"Univ. 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