{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:09:49Z","timestamp":1792249789380,"version":"4.4.0"},"reference-count":34,"publisher":"SPIE-Intl Soc Optical Eng","issue":"08","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:p>SignificancePathologies within the tympanic membrane (TM) and middle ear (ME) can lead to hearing loss. Imaging tools available in the hearing clinic for diagnosis and management are limited to visual inspection using the classic otoscope. The otoscopic view is limited to the surface of the TM, especially in diseased ears where the TM is opaque. An integrated optical coherence tomography (OCT) otoscope can provide images of the interior of the TM and ME space as well as an otoscope image. This enables the clinicians to correlate the standard otoscopic view with OCT and then use the new information to improve the diagnostic accuracy and management.AimWe aim to develop an OCT otoscope that can easily be used in the hearing clinic and demonstrate the system in the hearing clinic, identifying relevant image features of various pathologies not apparent in the standard otoscopic view.ApproachWe developed a portable OCT otoscope device featuring an improved field of view and form-factor that can be operated solely by the clinician using an integrated foot pedal to control image acquisition. The device was used to image patients at a hearing clinic.ResultsThe field of view of the imaging system was improved to a 7.4\u00a0mm diameter, with lateral and axial resolutions of 38 \u03bcm and 33.4 \u03bcm, respectively. We developed algorithms to resample the images in Cartesian coordinates after collection in spherical polar coordinates and correct the image aberration. We imaged over 100 patients in the hearing clinic at USC Keck Hospital. Here, we identify some of the pathological features evident in the OCT images and highlight cases in which the OCT image provided clinically relevant information that was not available from traditional otoscopic imaging.ConclusionsThe developed OCT otoscope can readily fit into the hearing clinic workflow and provide new relevant information for diagnosing and managing TM and ME disease.<\/jats:p>","DOI":"10.1117\/1.jbo.29.8.086005","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T10:16:25Z","timestamp":1724148985000},"page":"1-15","source":"Crossref","is-referenced-by-count":15,"title":["Optical coherence tomography otoscope for imaging of tympanic membrane and middle ear pathology"],"prefix":"10.1117","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-7215","authenticated-orcid":false,"given":"Wihan","family":"Kim","sequence":"first","affiliation":[{"name":"The Univ. of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0448-9271","authenticated-orcid":false,"given":"Ryan","family":"Long","sequence":"additional","affiliation":[{"name":"The Univ. of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-4725","authenticated-orcid":false,"given":"Zihan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Univ. of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-6189","authenticated-orcid":false,"given":"John S.","family":"Oghalai","sequence":"additional","affiliation":[{"name":"The Univ. of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-5678","authenticated-orcid":false,"given":"Brian E.","family":"Applegate","sequence":"additional","affiliation":[{"name":"The Univ. of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997586"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610529113"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-014-0181-x"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0981-8"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942011000300012"},{"key":"r6","article-title":"Table 2. 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