{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:05:26Z","timestamp":1790197526028,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"12","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82460185"],"award-info":[{"award-number":["82460185"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Natural Science Foundation Projects of Jiangxi Province","award":["20232ACB206028"],"award-info":[{"award-number":["20232ACB206028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:p>SignificanceOptical coherence elastography (OCE) is a noninvasive imaging technique with high sensitivity and resolution that can be used for mucocutaneous imaging. Oral submucous fibrosis (OSF) is a chronic disease that has a tendency to become cancerous. Nevertheless, there are a few noninvasive methods for early detection of OSF.AimA piezoelectric transducer-based (PZT) OCE technique was devised to noninvasively assess the structural and mechanical properties of mucosa in healthy and fibrotic oral diseases.ApproachWe first validated the accuracy and reliability of the OCE system for tissue elasticity detection by means of a heterogeneous agar model. The structural and biomechanical characteristics of the regional tissues were then evaluated by examining the oral mucosa of both healthy and fibrotic SD rats.ResultsNormal and fibrotic tissue stiffness differed significantly (p&lt;0.05). The elastic wave velocity was 6.44\u00b10.30 m\/s in the normal group and 14.2\u00b10.91 m\/s in the fibrotic group. After converting the results to Young\u2019s modulus, the stiffness of the healthy buccal tissues and the fibrotic buccal tissues were 130.71\u00b112.01 and 636.15\u00b179.17 kPa, respectively (p&lt;0.05).ConclusionsOCE can differentiate between normal and fibrotic tissue based on elasticity and optical properties. Healthy buccal tissues were softer than diseased tissues.<\/jats:p>","DOI":"10.1117\/1.jbo.30.12.124510","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:52:42Z","timestamp":1760683962000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["Noninvasive quantitative assessment of oral submucosal fibrosis in vivo using optical coherence elastography"],"prefix":"10.1117","volume":"30","author":[{"given":"Yuhao","family":"Yang","sequence":"first","affiliation":[{"name":"Nanchang Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Ye","sequence":"additional","affiliation":[{"name":"Nanchang Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhen","family":"Tang","sequence":"additional","affiliation":[{"name":"Nanchang Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekun","family":"Li","sequence":"additional","affiliation":[{"name":"Nanchang Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanchang Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdao","family":"He","sequence":"additional","affiliation":[{"name":"Nanchang Hangkong Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanchang Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-9772","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanchang Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-30\/issue-12\/124510\/Noninvasive-quantitative-assessment-of-oral-submucosal-fibrosis-in-vivo-using\/10.1117\/1.JBO.30.12.124510.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:34:52Z","timestamp":1790195692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-30\/issue-12\/124510\/Noninvasive-quantitative-assessment-of-oral-submucosal-fibrosis-in-vivo-using\/10.1117\/1.JBO.30.12.124510.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.30.12.124510","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]}}}