{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:36:07Z","timestamp":1793194567782,"version":"4.5.0"},"reference-count":66,"publisher":"SPIE-Intl Soc Optical Eng","issue":"03","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:p>SignificanceThe incidence of keratinocyte carcinomas (KCs) is increasing every year, making the task of developing new methods for KC early diagnosis of utmost medical and economical importance.AimWe aim to evaluate the KC diagnostic aid performance of an optical spectroscopy device associated with a machine-learning classification method.ApproachWe present the classification performance of autofluorescence and diffuse reflectance optical spectra obtained in vivo from 131 patients on four histological classes: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), actinic keratosis (AK), and healthy (H) skin. Classification accuracies obtained by support vector machine, discriminant analysis, and multilayer perceptron in binary- and multi-class modes were compared to define the best classification pipeline.ResultsThe accuracy of binary classification tests was &gt;80% to discriminate BCC or SCC from H. For AK versus other classes, the classification achieved a 65% to 75% accuracy. In multiclass (three or four classes) classification modes, accuracy reached 57%. Fusion of decisions increased classification accuracies (up to 10 percentage point-increase), proving the interest of multimodal spectroscopy compared with a single modality.ConclusionsSuch levels of classification accuracy are promising as they are comparable to those obtained by general practitioners in KC screening.<\/jats:p>","DOI":"10.1117\/1.jbo.30.3.035001","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T07:56:19Z","timestamp":1741074979000},"page":"1-25","source":"Crossref","is-referenced-by-count":5,"title":["Machine learning\u2013based classification of spatially resolved diffuse reflectance and autofluorescence spectra acquired on human skin for actinic keratoses and skin carcinoma diagnostics aid"],"prefix":"10.1117","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-0170","authenticated-orcid":false,"given":"Valentin","family":"Kupriyanov","sequence":"first","affiliation":[{"name":"Univ. de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5866-7228","authenticated-orcid":false,"given":"Walter","family":"Blondel","sequence":"additional","affiliation":[{"name":"Univ. de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Daul","sequence":"additional","affiliation":[{"name":"Univ. de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-1015","authenticated-orcid":false,"given":"Martin","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander-Univ. 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