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Biomed. Opt."],"published-print":{"date-parts":[[2025,5,16]]},"abstract":"<jats:p>SignificanceDiffuse correlation tomography (DCT) is an emerging technique for the noninvasive measurement of breast microvascular blood flow, whereas its capability to categorize benign and malignant breast lesions has not been extensively validated thus far, due to the difficulties in instrumentation, image reconstruction algorithms, and appropriate approaches for imaging analyses.AimThis artificial intelligence (AI)-assisted DCT instrumentation was constructed based on a unique source\u2013detector array and image reconstruction algorithm.ApproachThe DCT images of breasts were obtained from 61 females, and AI models were utilized to classify breast lesions. During this process, the blood flow images were either extracted as feature parameters or as global inputs to the AI models.ResultsAs the validations of DCT instrumentation, the blood flow images obtained from longitudinal monitoring of healthy subjects demonstrated the stability of DCT measurements. For patients with breast diseases, comprehensive analyses yield an AI-assisted classification with excellent performance for distinguishing between benign and malignant breast lesions, at an accuracy of 97%.ConclusionsThe AI-assisted DCT reflects functional abnormalities that are associated with cancellous-induced high metabolic demands, thus demonstrating the great potential for early diagnosis and timely therapeutic assessment of breast cancer, e.g., prior to the tumor formation or proliferation of microvascular networks.<\/jats:p>","DOI":"10.1117\/1.jbo.30.5.055001","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:18:36Z","timestamp":1747390716000},"page":"1-17","source":"Crossref","is-referenced-by-count":0,"title":["AI-assisted diffuse correlation tomography for identifying breast cancer"],"prefix":"10.1117","volume":"30","author":[{"given":"Ruizhi","family":"Zhang","sequence":"first","affiliation":[{"name":"North University of 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