{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:31Z","timestamp":1792787131872,"version":"4.5.0"},"reference-count":40,"publisher":"SPIE-Intl Soc Optical Eng","issue":"05","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Council of Saint-Joseph University of Beirut","award":["N\u00b0 50345WH"],"award-info":[{"award-number":["N\u00b0 50345WH"]}],"id":[{"id":"https:\/\/ror.org\/044fxjq88","id-type":"ROR","asserted-by":"crossref"}]},{"name":"CEDRE program","award":["N\u00b0 50345WH"],"award-info":[{"award-number":["N\u00b0 50345WH"]}]},{"name":"French National Research Agency (ANR) as part of the Investissements d\u2019Avenir program, through the \u201cADI\u201d project funded by the IDEX Paris-Saclay","award":["ANR-11-IDEX-0003-02"],"award-info":[{"award-number":["ANR-11-IDEX-0003-02"]}],"id":[{"id":"https:\/\/ror.org\/00rbzpz17","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:p>SignificanceBlue light exposure is ubiquitous in modern life, raising concerns about its potential impact on skin health.AimWe aim to explore the effects of blue light on the reconstructed human epidermis (RHE) using the speckle analysis technique.ApproachRHE samples were irradiated with controlled doses of blue light (415 and 455\u00a0nm) at defined stages of their maturation. Following irradiation, speckle analysis was performed to assess the impact of blue light on the skin barrier.ResultsOur results demonstrate that blue light irradiation significantly alters the scattering properties of RHE. Both wavelengths induced changes in the degree of linear polarization and speckle grain size, indicating disruptions in the skin barrier\u2019s structure and organization. The effects were found to be wavelength-dependent, with 455\u00a0nm irradiation showing more pronounced changes.ConclusionsSpeckle imaging allowed detection of changes in the scattering properties of RHE. Findings suggest that blue light exposure can influence skin barrier function and may have implications for skin health and related conditions.<\/jats:p>","DOI":"10.1117\/1.jbo.30.5.056001","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T20:59:01Z","timestamp":1746651541000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating blue light impact on reconstructed human epidermis using laser speckle imaging"],"prefix":"10.1117","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3109-289X","authenticated-orcid":false,"given":"L\u00e9a","family":"Habib","sequence":"first","affiliation":[{"name":"Saint Joseph Univ. of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4258-0427","authenticated-orcid":false,"given":"L\u00e9a","family":"Abi Nassif","sequence":"additional","affiliation":[{"name":"Saint Joseph Univ. of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-1001","authenticated-orcid":false,"given":"Marie","family":"Abboud","sequence":"additional","affiliation":[{"name":"Saint Joseph Univ. of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rime","family":"Michael-Jubeli","sequence":"additional","affiliation":[{"name":"Univ. 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