{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:33Z","timestamp":1792787133588,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"S2","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre","id":[{"id":"https:\/\/ror.org\/0187kwz08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Italian Ministry of University and Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2025,9,17]]},"abstract":"<jats:p>SignificanceInvasive neuromonitoring hinders the application of diffuse optical tomography (DOT) to critically ill adults in the intensive care unit (ICU).AimWe aim to develop and test a method for DOT recordings suitable for traumatic brain injury (TBI) patients in the ICU. This method is based on measurements and coregistration using a 3D optical scan and the acquisition of optical data using a custom-made helmet, which would enable a multimodal (invasive and noninvasive) neuromonitoring.ApproachCoregistration accuracy between the method based on a 3D optical scan and one based on an electromagnetic digitization, the latter considered to be the gold standard, was assessed. The capacity to isolate and monitor, using functional near-infrared spectroscopy, the optical signal in the intracranial (ICT), and extracranial tissues (ECT), was tested on 23 healthy volunteers. Participants were scanned with a frequency-domain NIRS device (690 and 830\u00a0nm) during 5 Valsalva maneuvers (VM) in a simulated ICU environment.ResultsThe results showed an average error of coregistration of 5.5\u00a0mm and a sufficient capacity to isolate oxyhemoglobin (O2Hb) (p=6.4\u00b710\u22126) and total hemoglobin (HbT) (p=2.8\u00b710\u22125) in the ICT from the ECT and to follow the changes of hemoglobin in the ICT during the VM (O2Hb, p=9.2\u00b710\u22124; HbT, p=1.0\u00b710\u22123).ConclusionThe developed approach appears to be suitable for use on TBI patients in the ICU in a multimodal monitoring.<\/jats:p>","DOI":"10.1117\/1.jbo.30.s2.s23912","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:29:24Z","timestamp":1758126564000},"page":"1-18","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers"],"prefix":"10.1117","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-8011","authenticated-orcid":false,"given":"Mario","family":"Forcione","sequence":"first","affiliation":[{"name":"Univ. of Birmingham,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Univ. degli Studi G. d'Annunzio Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-0501","authenticated-orcid":false,"given":"David","family":"Perpetuini","sequence":"additional","affiliation":[{"name":"Univ. degli Studi G. d'Annunzio Chieti-Pescara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-9324","authenticated-orcid":false,"given":"Guy A.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Univ. of Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-133X","authenticated-orcid":false,"given":"Andrew  .","family":"Stevens","sequence":"additional","affiliation":[{"name":"Univ. of Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David  J.","family":"Davies","sequence":"additional","affiliation":[{"name":"Univ. of Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Belli","sequence":"additional","affiliation":[{"name":"Univ. of Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-30\/issue-S2\/S23912\/Diffuse-optical-tomography-system-for-acute-traumatic-brain-injury-in\/10.1117\/1.JBO.30.S2.S23912.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:39:30Z","timestamp":1790195970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-30\/issue-S2\/S23912\/Diffuse-optical-tomography-system-for-acute-traumatic-brain-injury-in\/10.1117\/1.JBO.30.S2.S23912.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":0,"journal-issue":{"issue":"S2","published-online":{"date-parts":[[2025,2,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.30.s2.s23912","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}