{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:33Z","timestamp":1792787133687,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"04","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taichung Veterans General Hospital","award":["TCVGH-YM1090104"],"award-info":[{"award-number":["TCVGH-YM1090104"]}],"id":[{"id":"https:\/\/ror.org\/00e87hq62","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:p>SignificanceNon-invasive optical measures for evaluating rheumatoid arthritis (RA) remain limited. Clinical scores such as the 28-joint Disease Activity Score (DAS28) and ultrasound are operator-dependent and do not directly quantify optical tissue changes. Short-wave infrared (SWIR) hyperspectral imaging (HSI) provides sensitivity to inflammation-associated spectral changes in biological tissues.AimThe aim is to develop and evaluate a quantitative HSI soft abundance scoring (HSISAS) method for assessing treatment response in RA patients using SWIR-HSI.ApproachEleven RA patients who met the 2010 American College of Rheumatology\/European Alliance of Associations for Rheumatology criteria underwent SWIR-HSI (900 to 1700\u00a0nm) of the wrist joints before and after 12 weeks of biologic therapy. The HSISAS algorithm used pixel-wise reflectance spectra together with spectral correlation structure estimation and constrained energy minimization-based abundance scoring to compute intra- and inter-subject scores. These scores were statistically compared with conventional clinical indices, including DAS28, erythrocyte sedimentation rate, C-reactive protein, and power Doppler ultrasound findings.ResultsBoth intra- and inter-HSISAS significantly increased after treatment (p&lt;0.001) and were positively associated with DAS28 improvement. Reflectance spectra showed visible pre\/post-treatment differences, particularly near 1250\u00a0nm. The abundance maps visually differentiated pre- and post-treatment states consistent with clinical improvement.ConclusionsThe HSISAS framework provides a quantitative, non-contact optical measure of treatment-related spectral changes in RA. This method may offer translational potential for disease monitoring and may complement existing ultrasound and laboratory assessments.<\/jats:p>","DOI":"10.1117\/1.jbo.31.4.045001","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:12:55Z","timestamp":1777389175000},"page":"1-16","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative assessment of rheumatoid arthritis treatment response using short-wave infrared hyperspectral imaging soft abundance scoring"],"prefix":"10.1117","volume":"31","author":[{"given":"Hsin-Hua","family":"Chen","sequence":"first","affiliation":[{"name":"Chung Hsing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Che","family":"Wang","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Lung","family":"Lai","sequence":"additional","affiliation":[{"name":"National Chung Hsing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Chin","family":"Sung","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Fu","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Jen","family":"Weng","sequence":"additional","affiliation":[{"name":"Tunghai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-3237","authenticated-orcid":false,"given":"Hsian-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-04\/045001\/Quantitative-assessment-of-rheumatoid-arthritis-treatment-response-using-short-wave\/10.1117\/1.JBO.31.4.045001.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:10:52Z","timestamp":1790194252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-04\/045001\/Quantitative-assessment-of-rheumatoid-arthritis-treatment-response-using-short-wave\/10.1117\/1.JBO.31.4.045001.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.31.4.045001","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}