{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:34Z","timestamp":1792787134115,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"04","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2167-390884018"],"award-info":[{"award-number":["EXC 2167-390884018"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Bundesministerium f\u00fcr Bildung und Forschung","award":["13GW0227B"],"award-info":[{"award-number":["13GW0227B"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Bundesministerium f\u00fcr Wirtschaft und Klimaschutz","award":["KK5143004AB3"],"award-info":[{"award-number":["KK5143004AB3"]}],"id":[{"id":"https:\/\/ror.org\/02vgg2808","id-type":"ROR","asserted-by":"crossref"}]},{"name":"H2020 Marie Sk\u0142odowska-Curie Actions","award":["860807"],"award-info":[{"award-number":["860807"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:p>SignificanceEndoscopic optical coherence tomography (OCT) is a valuable tool for rectal imaging, enabling noninvasive visualization of transmural structures with near-histological resolution, critical for accurate tumor staging and diagnostic\/therapeutic monitoring. However, anatomical variability of the rectum and the resulting changes in tissue-to-probe distance challenge optimal circumferential imaging.AimWe aim to develop a dual-mode endoscopic OCT system, enabling real-time switching between high-detail and extended-range imaging for improved assessment of rectal wall morphology under varying anatomical conditions.ApproachA single fiber-optic ferrule containing two fibers with differing mode fields was integrated into a MHz-OCT rectoscope, enabling an extended-range mode for full circumferential imaging and a high-detail mode for close examination of fine structures with seamless live switching mechanism. The system was tested in situ on a postmortem human rectum preserved with ethanol-glycerol-lysoformin fixation.ResultsPostmortem rectum imaging demonstrated the feasibility of real-time switching between the two modes. Extended-range imaging provided full circumferential coverage, whereas high-detail imaging revealed distinct rectal wall layers and fine transmural structures, validated by histological correlation.ConclusionsThe dual-mode MHz-OCT system offers a flexible and practical solution for adaptive rectal imaging, providing high-resolution detail and full circumferential coverage with the potential to enhance diagnostics and treatment monitoring.<\/jats:p>","DOI":"10.1117\/1.jbo.31.4.046002","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:57:46Z","timestamp":1774605466000},"page":"1-16","source":"Crossref","is-referenced-by-count":0,"title":["Dual-resolution megahertz optical coherence tomography prototype rectoscope for enhanced visualization of colorectal microstructures"],"prefix":"10.1117","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4135-1197","authenticated-orcid":false,"given":"Sazgar","family":"Burhan","sequence":"first","affiliation":[{"name":"Universit\u00e4t zu L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Schulte","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5992-9274","authenticated-orcid":false,"given":"Madita","family":"G\u00f6b","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awanish Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu 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L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeine","family":"Saker","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-790X","authenticated-orcid":false,"given":"Tim","family":"Eixmann","sequence":"additional","affiliation":[{"name":"Medizinisches Laserzentrum L\u00fcbeck GmbH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Heimke","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University of Kiel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tillmann","family":"Heinze","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-Univ zu Kiel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Wedel","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-Univ zu Kiel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Rahlves","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ellrichmann","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-6574","authenticated-orcid":false,"given":"Robert","family":"Huber","sequence":"additional","affiliation":[{"name":"Universit\u00e4t zu L\u00fcbeck"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-04\/046002\/Dual-resolution-megahertz-optical-coherence-tomography-prototype-rectoscope-for-enhanced\/10.1117\/1.JBO.31.4.046002.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:14:43Z","timestamp":1790194483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-04\/046002\/Dual-resolution-megahertz-optical-coherence-tomography-prototype-rectoscope-for-enhanced\/10.1117\/1.JBO.31.4.046002.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.31.4.046002","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}