{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:33Z","timestamp":1792787133268,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"07","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Commission of Shanghai Municipality","award":["25xtcx00600"],"award-info":[{"award-number":["25xtcx00600"]}],"id":[{"id":"https:\/\/ror.org\/03kt66j61","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Ruijin Hospital Ethics Committee","award":["AF0406\/14.0\/2023-03-01"],"award-info":[{"award-number":["AF0406\/14.0\/2023-03-01"]}],"id":[{"id":"https:\/\/ror.org\/01hv94n30","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2026,7,6]]},"abstract":"<jats:p>SignificanceDestructive staining and slow subjective visual inspection remain major limitations in rapid evaluation of biopsy specimens during endoscopic ultrasound-guided fine needle biopsy. Therefore, there is a strong need for a label-free optical imaging approach that enables quantitative specimen assessment while preserving specimen integrity.AimA multimodal imaging system integrating hyperspectral and color imaging was developed to acquire images of biopsy specimens without staining or sample preparation.ApproachA hyperspectral on-site evaluation workflow was proposed, integrating hyperspectral imaging and color imaging within a modular platform. Hyperspectral data were analyzed using a support-vector-machine-based segmentation framework for specimen assessment with color images providing reference annotations. No washing or staining is required.ResultsValidation on 220 pancreatic biopsy specimens demonstrates accurate non-destructive macroscopic visible core evaluation, achieving an F1-score of 94.7%. The proposed workflow improves analysis efficiency by 93% compared with conventional rapid on-site evaluation.ConclusionsWe demonstrate that integrating hyperspectral imaging with computational analysis enables rapid, quantitative, and label-free specimen evaluation, highlighting the potential of biomedical optical systems for intra-procedural specimen assessment.<\/jats:p>","DOI":"10.1117\/1.jbo.31.7.076502","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:07:49Z","timestamp":1783361269000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Multimodal imaging platform for rapid non-destructive evaluation of pancreatic puncture specimens"],"prefix":"10.1117","volume":"31","author":[{"given":"Jianan","family":"Zhang","sequence":"first","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansheng","family":"Wang","sequence":"additional","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Gao","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[{"name":"Four Districts for Convalescence of Air Force Hangzhou Special Service Recuperation Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duowu","family":"Zou","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5063-8801","authenticated-orcid":false,"given":"Qingli","family":"Li","sequence":"additional","affiliation":[{"name":"East China Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-07\/076502\/Multimodal-imaging-platform-for-rapid-non-destructive-evaluation-of-pancreatic\/10.1117\/1.JBO.31.7.076502.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:02:17Z","timestamp":1790193737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-07\/076502\/Multimodal-imaging-platform-for-rapid-non-destructive-evaluation-of-pancreatic\/10.1117\/1.JBO.31.7.076502.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.31.7.076502","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}