{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:08:03Z","timestamp":1790194083597,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"09","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Glaukos Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:p>SignificanceEpithelium-off corneal collagen cross-linking (CXL) has drawbacks related to epithelial removal. Earlier epithelium-on approaches without supplemental oxygen showed limited efficacy due to inadequate permeation of the photoenhancer and oxygen into the corneal stroma. Improved epithelium-on CXL with improved photoenhancer permeation and supplemental oxygen has demonstrated effective cross-linking in two phase 3 trials.AimThe study aims to evaluate the effect of supplemental oxygen during epithelium-on CXL in an ex vivo animal study mirroring the clinical CXL procedure, using an in-house built optical coherence elastography (OCE) system that measures biomechanical changes (stiffness) in the cornea.ApproachEpithelium-on CXL was performed on two groups of ex vivo rabbit eyes at a UV fluence of 10 J\/cm2 and irradiance of 30 mW\/cm2. Eyes in Group 1 were treated under normoxic (ambient air, 21% oxygen) conditions, whereas eyes in Group 2 were treated under hyperoxic (&gt;90% oxygen) conditions.ResultsForty eyes treated under hyperoxic conditions and pulsed illumination exhibited a statistically significant greater increase (p&lt;0.0001) in shear modulus (81% larger increase), as a measure of stiffness, compared with eyes treated under normoxic conditions.ConclusionsThese results strongly suggest that the use of supplemental oxygen during epithelium-on CXL produces stronger inter-corneal collagen cross-links and greatly improves corneal stiffness, potentially lessening or preventing the risk of vision loss for patients with keratoconus.<\/jats:p>","DOI":"10.1117\/1.jbo.31.9.095002","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:53:51Z","timestamp":1788929631000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Biomechanical assessments of high-fluence corneal cross-linking with supplemental oxygen using optical coherence elastography in ex vivo rabbit eyes"],"prefix":"10.1117","volume":"31","author":[{"given":"Vance","family":"Thompson","sequence":"first","affiliation":[{"name":"Vance Thompson Vision"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Beckman","sequence":"additional","affiliation":[{"name":"Comprehensive EyeCare of Central Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Rajpal","sequence":"additional","affiliation":[{"name":"See Clearly Vision Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-8280","authenticated-orcid":false,"given":"Behrouz","family":"Tavakol","sequence":"additional","affiliation":[{"name":"Glaukos Corp."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Elmhurst","sequence":"additional","affiliation":[{"name":"Glaukos Corp."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Usher","sequence":"additional","affiliation":[{"name":"Glaukos Corp."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Hill","sequence":"additional","affiliation":[{"name":"Glaukos Corp."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3577-3096","authenticated-orcid":false,"given":"Tomas","family":"Navratil","sequence":"additional","affiliation":[{"name":"Glaukos Corp."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-09\/095002\/Biomechanical-assessments-of-high-fluence-corneal-cross-linking-with-supplemental\/10.1117\/1.JBO.31.9.095002.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:55:10Z","timestamp":1790193310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-09\/095002\/Biomechanical-assessments-of-high-fluence-corneal-cross-linking-with-supplemental\/10.1117\/1.JBO.31.9.095002.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.31.9.095002","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]}}}