{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:07:48Z","timestamp":1790194068121,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"09","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["40947457"],"award-info":[{"award-number":["40947457"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:p>SignificanceTo remove the entire tumor area in cancer surgery, the margins are currently assessed by frozen sectioning or by analyzing the resected tissue afterwards. By utilizing spectral differences between healthy and malignant tissue, multispectral imaging (MSI) enables real-time tissue differentiation. Through miniaturization, the system can be used intraoperatively, thereby enabling the surgeon to define tumor margins, which reduces the need for a follow-up surgery.AimBy obtaining characteristic spectral differences of healthy and malignant breast tissue, a miniaturized multispectral sensor system should be developed. The system should be compatible to commercial endoscopes, so that it can be used in minimally invasive endoscopic procedures.ApproachWe analyzed hyperspectral measurements of an ex vivo breast cancer study in the visible to shortwave infrared spectral range (450 to 1390\u00a0nm) and defined characteristic spectral differences. With these, we designed two MSI sensor systems, which only use few spectral channels, gaining a potentially real-time-capable sensor system. By miniaturization, they can be used intraoperatively with a commercial endoscope.ResultsThe final setups can be used with a commercial endoscope and allow for 90\u00a0deg field of view and a high spatial resolution, but showed limitations in the SWIR transmission.ConclusionThe two demonstrated systems are promising steps towards real-time endoscopic tissue differentiation.<\/jats:p>","DOI":"10.1117\/1.jbo.31.9.097003","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:56:36Z","timestamp":1790103396000},"page":"1-24","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic multispectral imaging sensor systems for intraoperative tissue differentiation"],"prefix":"10.1117","volume":"31","author":[{"given":"Kira","family":"Holstein","sequence":"additional","affiliation":[{"name":"University of Stuttgart, Institute of Applied Optics (ITO), Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Tarnoruzki","sequence":"additional","affiliation":[{"name":"University of Stuttgart, Institute of Applied Optics (ITO), Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Haist","sequence":"additional","affiliation":[{"name":"University of Stuttgart, Institute of Applied Optics (ITO), Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-0708","authenticated-orcid":false,"given":"Stephan","family":"Reichelt","sequence":"additional","affiliation":[{"name":"University of Stuttgart, Institute of Applied Optics (ITO), Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-09\/097003\/Endoscopic-multispectral-imaging-sensor-systems-for-intraoperative-tissue-differentiation\/10.1117\/1.JBO.31.9.097003.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:53:49Z","timestamp":1790193229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-09\/097003\/Endoscopic-multispectral-imaging-sensor-systems-for-intraoperative-tissue-differentiation\/10.1117\/1.JBO.31.9.097003.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.31.9.097003","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}