{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:53Z","timestamp":1790697953851,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"09","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bm1123032"],"award-info":[{"award-number":["JP23bm1123032"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/004rtk039","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJMS2021"],"award-info":[{"award-number":["JPMJMS2021"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/00097mb19","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Japan Society for the Promotion of Science","award":["25K03067"],"award-info":[{"award-number":["25K03067"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Opt."],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:p>SignificanceThe molecular pathogenesis of degenerative alterations in articular cartilage is still not fully understood. Raman spectroscopy using a fiber-optic probe system is a promising approach for the early diagnosis and prevention of joint disorders such as osteoarthritis.AimThis study aims to characterize the degenerative changes in the joint articular cartilage using a hollow-core fiber Raman probe designed for future arthroscopic use.ApproachHuman articular cartilage specimens were obtained from 12 patients who underwent knee (n=5) or shoulder (n=7) arthroplasty. All surgical specimens were measured ex vivo after fixation in 10% neutral buffered formalin. The articular cartilage tissues at the knee, hip, and shoulder joints were obtained from a single cadaver donor. Raman spectra of the cartilage specimens were acquired and analyzed using a handheld Raman probe system.ResultsThe hollow-core fiber Raman probe detected molecular differences between less-degenerated and degenerated areas in human shoulder and knee articular cartilage ex vivo, with clearer separation in the knee, and additionally revealed joint-specific baseline spectral features among cadaveric shoulder, hip, and knee cartilage.ConclusionsThese results support the novelty and translational potential of this probe as a future in vivo arthroscopic tool for objective molecular assessment of cartilage degeneration.<\/jats:p>","DOI":"10.1117\/1.jbo.31.9.097005","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:42:29Z","timestamp":1790660549000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological analysis for human articular cartilage using a Raman probe system"],"prefix":"10.1117","volume":"31","author":[{"given":"Hiroshi","family":"Kiyomatsu","sequence":"first","affiliation":[{"name":"Ehime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Toda","sequence":"additional","affiliation":[{"name":"University of Toyama, Graduate School of Pharma-Medical Sciences, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Katagiri","sequence":"additional","affiliation":[{"name":"University of Toyama, Research Center for Pre-Disease Science, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"University of Toyama, Research Center for Pre-Disease Science, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-6315","authenticated-orcid":false,"given":"Tatsuhiko","family":"Kutsuna","sequence":"additional","affiliation":[{"name":"Ehime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomofumi","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Ehime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Ehime University Graduate School of Medicine, Department of Orthopaedic Surgery, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Biomedical Optics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-09\/097005\/Histopathological-analysis-for-human-articular-cartilage-using-a-Raman-probe\/10.1117\/1.JBO.31.9.097005.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:33:23Z","timestamp":1790696003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-biomedical-optics\/volume-31\/issue-09\/097005\/Histopathological-analysis-for-human-articular-cartilage-using-a-Raman-probe\/10.1117\/1.JBO.31.9.097005.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jbo.31.9.097005","relation":{},"ISSN":["1083-3668","1560-2281"],"issn-type":[{"value":"1083-3668","type":"print"},{"value":"1560-2281","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]}}}