{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:48:15Z","timestamp":1791409695337,"version":"4.3.3"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"03","funder":[{"name":"National Center for Research Resources","award":["UL1 RR024975-01"],"award-info":[{"award-number":["UL1 RR024975-01"]}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources (NCRR) of the National Institute of Health","doi-asserted-by":"publisher","award":["UL1 RR024975-01"],"award-info":[{"award-number":["UL1 RR024975-01"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 RR024975-01"],"award-info":[{"award-number":["UL1 RR024975-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"HHS|NIH| National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1 RR024975-01"],"award-info":[{"award-number":["UL1 RR024975-01"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR000445-06"],"award-info":[{"award-number":["UL1 TR000445-06"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000445-06"],"award-info":[{"award-number":["UL1 TR000445-06"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/04pw6fb54","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Institutes of Health (NIH)\/National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000445-06"],"award-info":[{"award-number":["UL1 TR000445-06"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/NEI","award":["R21EY024036"],"award-info":[{"award-number":["R21EY024036"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R03EB012461"],"award-info":[{"award-number":["1R03EB012461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["1R03EB012461"],"award-info":[{"award-number":["1R03EB012461"]}]},{"name":"NIH\/NIBIB","award":["1R03EB012461"],"award-info":[{"award-number":["1R03EB012461"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["1R03EB012461"],"award-info":[{"award-number":["1R03EB012461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/NIBIB","award":["K01EB009120"],"award-info":[{"award-number":["K01EB009120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Imag."],"published-print":{"date-parts":[[2014,12,17]]},"abstract":"<jats:p>The optic nerve (ON) plays a critical role in many devastating pathological conditions. Segmentation of the ON has the ability to provide understanding of anatomical development and progression of diseases of the ON. Recently, methods have been proposed to segment the ON but progress toward full automation has been limited. We optimize registration and fusion methods for a new multi-atlas framework for automated segmentation of the ONs, eye globes, and muscles on clinically acquired computed tomography (CT) data. Briefly, the multi-atlas approach consists of determining a region of interest within each scan using affine registration, followed by nonrigid registration on reduced field of view atlases, and performing statistical fusion on the results. We evaluate the robustness of the approach by segmenting the ON structure in 501 clinically acquired CT scan volumes obtained from 183 subjects from a thyroid eye disease patient population. A subset of 30 scan volumes was manually labeled to assess accuracy and guide method choice. Of the 18 compared methods, the ANTS Symmetric Normalization registration and nonlocal spatial simultaneous truth and performance level estimation statistical fusion resulted in the best overall performance, resulting in a median Dice similarity coefficient of 0.77, which is comparable with inter-rater (human) reproducibility at 0.73.<\/jats:p>","DOI":"10.1117\/1.jmi.1.3.034006","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T13:56:01Z","timestamp":1418910961000},"page":"1-9","source":"Crossref","is-referenced-by-count":34,"title":["Robust optic nerve segmentation on clinically acquired computed tomography"],"prefix":"10.1117","volume":"1","author":[{"given":"Robert L.","family":"Harrigan","sequence":"first","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetasudha","family":"Panda","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Asman","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Chaganti","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4591-5151","authenticated-orcid":false,"given":"Michael P.","family":"DeLisi","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin C.  W.","family":"Yvernault","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Galloway","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise A.","family":"Mawn","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-2127","authenticated-orcid":false,"given":"Bennett A.","family":"Landman","sequence":"additional","affiliation":[{"name":"Vanderbilt Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Medical Imaging"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-1\/issue-03\/034006\/Robust-optic-nerve-segmentation-on-clinically-acquired-computed-tomography\/10.1117\/1.JMI.1.3.034006.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:15:42Z","timestamp":1790892942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-1\/issue-03\/034006\/Robust-optic-nerve-segmentation-on-clinically-acquired-computed-tomography\/10.1117\/1.JMI.1.3.034006.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,17]]},"references-count":0,"journal-issue":{"issue":"03"},"URL":"https:\/\/doi.org\/10.1117\/1.jmi.1.3.034006","relation":{},"ISSN":["2329-4302","2329-4310"],"issn-type":[{"value":"2329-4302","type":"print"},{"value":"2329-4310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,17]]}}}