{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:09:55Z","timestamp":1790212195976,"version":"4.1.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"01","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Imag."],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:p>PurposeWe hypothesize that in vivo respiratory-gated micro computed tomography (micro-CT) imaging can noninvasively provide structural and functional information about the lungs in a cigarette-exposure model of chronic obstructive pulmonary disease in mice.ApproachFemale C57BL\/6 mice were exposed to cigarette smoke or ambient air for 1, 3, or 6 months. Each mouse received a respiratory-gated micro-CT scan at baseline and another scan following the exposure period, while anaesthetized and free-breathing. Images were obtained representing end-expiration and peak inspiration, and measurements were performed to characterize the lung structure and compute functional metrics. Following the final micro-CT session, the mice were euthanized and the lungs prepared for histology.ResultsFollowing 6 months of smoke-exposure, the mice exhibited larger increases in end-expiration lung volume and functional residual capacity, and a reduction in weight gain when compared with air-exposed mice. The histogram of CT numbers in the lung obtained during end-expiration also showed a shift to lower CT numbers following 6 months of smoke-exposure, indicating increased air content within the lungs. The metrics suggested air-trapping in the lung, which is consistent with emphysema. In the 3-month exposure group, only the reduction in weight gain was significant compared with the air-exposed group. Histological analysis confirmed that the 6-month smoke-exposed mice likely developed centrilobular emphysema as measured by the mean linear intercept.ConclusionsRespiratory-gated micro-CT imaging of free-breathing mice at multiple respiratory phases is noninvasive and provides additional information about lung structure and function that complements postmortem techniques and could be used to monitor changes over time.<\/jats:p>","DOI":"10.1117\/1.jmi.10.1.016002","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T02:35:55Z","timestamp":1676514955000},"page":"1-17","source":"Crossref","is-referenced-by-count":2,"title":["In vivo measurements of lung function using respiratory-gated micro-computed tomography in a smoke-exposure model of chronic obstructive pulmonary disease"],"prefix":"10.1117","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-1291","authenticated-orcid":false,"given":"Nancy L.","family":"Ford","sequence":"first","affiliation":[{"name":"The Univ. of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Lee","sequence":"additional","affiliation":[{"name":"The Univ. of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hwangbo","sequence":"additional","affiliation":[{"name":"The Univ. of British Columbia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Tam","sequence":"additional","affiliation":[{"name":"Ctr. for Heart Lung Innovation, St. Paul\u2019s Hospital, The Univ of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don D.","family":"Sin","sequence":"additional","affiliation":[{"name":"Ctr. for Heart Lung Innovation, St. Paul\u2019s Hospital, The Univ. of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Medical Imaging"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-10\/issue-01\/016002\/In-vivo-measurements-of-lung-function-using-respiratory-gated-micro\/10.1117\/1.JMI.10.1.016002.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:54:11Z","timestamp":1790211251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-10\/issue-01\/016002\/In-vivo-measurements-of-lung-function-using-respiratory-gated-micro\/10.1117\/1.JMI.10.1.016002.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jmi.10.1.016002","relation":{},"ISSN":["2329-4302","2329-4310"],"issn-type":[{"value":"2329-4302","type":"print"},{"value":"2329-4310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}