{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:26:13Z","timestamp":1792898773586,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"01","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Imag."],"published-print":{"date-parts":[[2025,1,30]]},"abstract":"<jats:p>PurposeUltra-high dose-rate radiotherapy (FLASH-RT) shows the potential to eliminate tumors while sparing healthy tissues. To investigate radiation-induced lung damage, we used in vivo respiratory-gated micro-computed tomography (micro-CT) to monitor mice that received photon FLASH-RT or conventional RT on the FLASH irradiation research station at TRIUMF.ApproachThirty healthy male C57BL\/6 mice received baseline micro-CT scans followed by radiation therapy targeting the thorax. Treatments administered included no irradiation, 10-MV photon FLASH-RT, and 10-MV conventional RT with either 15 or 30\u00a0Gy prescribed dose. Follow-up micro-CT scans were obtained up to 24 weeks post-irradiation, and histology was obtained at the experimental endpoint. Lung volume and CT number were measured during peak inspiration and end-expiration and used to calculate the functional residual capacity (FRC) and tidal volume (VT).ResultsRadiation pneumonitis was observed sporadically in micro-CT images at 9 and 12 weeks post-irradiation. Fibrosis was observed in the endpoint images and confirmed with histology. Compared with the 15-Gy treatment groups and unirradiated controls, the micro-CT images for 30-Gy FLASH-RT showed differences during peak inspiration, with a significant reduction in VT, whereas the 30-Gy conventional RT showed differences during end-expiration, with a significant difference in FRC from 15\u00a0Gy. Between 12 weeks and the endpoint, the 30-Gy conventional RT group exhibited the largest reduction in lung volume.ConclusionsRespiratory-gated micro-CT imaging was sensitive to radiation pneumonitis and fibrosis. Significant differences were seen in functional metrics measured at the endpoint for FRC (both 30-Gy groups) and VT (30-Gy FLASH-RT) compared with the control.<\/jats:p>","DOI":"10.1117\/1.jmi.12.1.014002","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:09Z","timestamp":1738195209000},"page":"1-12","source":"Crossref","is-referenced-by-count":7,"title":["Respiratory-gated micro-computed tomography imaging to measure radiation-induced lung injuries in mice following ultra-high dose-rate and conventional dose-rate radiation therapy"],"prefix":"10.1117","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-1291","authenticated-orcid":false,"given":"Nancy L.","family":"Ford","sequence":"first","affiliation":[{"name":"The Univ. of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Ren","sequence":"additional","affiliation":[{"name":"The Univ. of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Egoriti","sequence":"additional","affiliation":[{"name":"The Univ. of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolan","family":"Esplen","sequence":"additional","affiliation":[{"name":"Univ. of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Radel","sequence":"additional","affiliation":[{"name":"TRIUMF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Humphries","sequence":"additional","affiliation":[{"name":"TRIUMF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Wen","family":"Koay","sequence":"additional","affiliation":[{"name":"TRIUMF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Planche","sequence":"additional","affiliation":[{"name":"Univ.of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Hoehr","sequence":"additional","affiliation":[{"name":"Univ. of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gottberg","sequence":"additional","affiliation":[{"name":"Univ. of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-2889","authenticated-orcid":false,"given":"Magdalena","family":"Bazalova-Carter","sequence":"additional","affiliation":[{"name":"Univ. of Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Medical Imaging"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-12\/issue-01\/014002\/Respiratory-gated-micro-computed-tomography-imaging-to-measure-radiation-induced\/10.1117\/1.JMI.12.1.014002.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:27:34Z","timestamp":1790206054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-12\/issue-01\/014002\/Respiratory-gated-micro-computed-tomography-imaging-to-measure-radiation-induced\/10.1117\/1.JMI.12.1.014002.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.jmi.12.1.014002","relation":{},"ISSN":["2329-4302","2329-4310"],"issn-type":[{"value":"2329-4302","type":"print"},{"value":"2329-4310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]}}}