{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:41Z","timestamp":1792787141573,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"03","funder":[{"name":"National Institute of Dental an Craniofacial Research of the National Institutes of Health","award":["R01DE024450"],"award-info":[{"award-number":["R01DE024450"]}],"id":[{"id":"https:\/\/ror.org\/004a2wv92","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Sao Paulo Research Foundation","award":["2013\/22417-0"],"award-info":[{"award-number":["2013\/22417-0"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Imag."],"published-print":{"date-parts":[[2015,7,7]]},"abstract":"<jats:p>This study aimed to investigate imaging statistical approaches for classifying three-dimensional (3-D) osteoarthritic morphological variations among 169 temporomandibular joint (TMJ) condyles. Cone-beam computed tomography scans were acquired from 69 subjects with long-term TMJ osteoarthritis (OA), 15 subjects at initial diagnosis of OA, and 7 healthy controls. Three-dimensional surface models of the condyles were constructed and SPHARM-PDM established correspondent points on each model. Multivariate analysis of covariance and direction-projection-permutation (DiProPerm) were used for testing statistical significance of the differences between the groups determined by clinical and radiographic diagnoses. Unsupervised classification using hierarchical agglomerative clustering was then conducted. Compared with healthy controls, OA average condyle was significantly smaller in all dimensions except its anterior surface. Significant flattening of the lateral pole was noticed at initial diagnosis. We observed areas of 3.88-mm bone resorption at the superior surface and 3.10-mm bone apposition at the anterior aspect of the long-term OA average model. DiProPerm supported a significant difference between the healthy control and OA group (p-value=0.001). Clinically meaningful unsupervised classification of TMJ condylar morphology determined a preliminary diagnostic index of 3-D osteoarthritic changes, which may be the first step towards a more targeted diagnosis of this condition.<\/jats:p>","DOI":"10.1117\/1.jmi.2.3.034501","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T03:31:01Z","timestamp":1436326261000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Diagnostic index of three-dimensional osteoarthritic changes in temporomandibular joint condylar morphology"],"prefix":"10.1117","volume":"2","author":[{"given":"Liliane R.","family":"Gomes","sequence":"first","affiliation":[{"name":"Univ. of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Univ. of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Jung","sequence":"additional","affiliation":[{"name":"The Univ. of North Carolina at Chapel Hill School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Paniagua","sequence":"additional","affiliation":[{"name":"The Univ. of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.","family":"Ruellas","sequence":"additional","affiliation":[{"name":"Univ. of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o R.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Univ. Estadual Paulista \"J\u00falio de Mesquita Filho\""}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Styner","sequence":"additional","affiliation":[{"name":"The Univ. of North Carolina at Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry M.","family":"Wolford","sequence":"additional","affiliation":[{"name":"Univ. Federal of Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Cevidanes","sequence":"additional","affiliation":[{"name":"Univ. of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Journal of Medical Imaging"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-2\/issue-03\/034501\/Diagnostic-index-of-three-dimensional-osteoarthritic-changes-in-temporomandibular-joint\/10.1117\/1.JMI.2.3.034501.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:15:48Z","timestamp":1790892948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/journal-of-medical-imaging\/volume-2\/issue-03\/034501\/Diagnostic-index-of-three-dimensional-osteoarthritic-changes-in-temporomandibular-joint\/10.1117\/1.JMI.2.3.034501.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,7]]},"references-count":0,"journal-issue":{"issue":"03"},"URL":"https:\/\/doi.org\/10.1117\/1.jmi.2.3.034501","relation":{},"ISSN":["2329-4302","2329-4310"],"issn-type":[{"value":"2329-4302","type":"print"},{"value":"2329-4310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,7]]}}}