{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:25:53Z","timestamp":1792787153999,"version":"4.5.0"},"reference-count":0,"publisher":"SPIE-Intl Soc Optical Eng","issue":"03","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3 CELLEX Barcelona","id":[{"id":"https:\/\/ror.org\/019dmpq73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundaci\u00f3 Mir-Puig, Agencia Estatal de Investigaci\u00f3n","id":[{"id":"https:\/\/ror.org\/003x0zc53","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the \u201cSevero Ochoa\u201d Programme for Centres of Excellence in R&D"},{"name":"LUX4MED and MEDLUX special programs"},{"name":"Generalitat de Catalunya","id":[{"id":"https:\/\/ror.org\/01bg62x04","id-type":"ROR","asserted-by":"crossref"}]},{"name":"FEDER EC"},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["675332"],"award-info":[{"award-number":["675332"]}]},{"name":"LASERLAB-EUROPE V","award":["871124"],"award-info":[{"award-number":["871124"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurophoton."],"published-print":{"date-parts":[[2026,9,17]]},"abstract":"<jats:p>SignificanceIt is hypothesized that neurocritical-care targeting cerebral autoregulation (CAR) would lead to improved outcomes. However, there is no single accepted CAR index due to limited accessibility of the methods and the complexity of interpretation. It is imperative to introduce accessible and direct methods.AimWe aim to compare traditional CAR indices and those on hybrid near-infrared diffuse optical (DO) monitors on a clinical population undergoing a controlled intervention.ApproachTraumatic brain injury patients undergoing a hyperventilation protocol were monitored. Seven CAR indices based on the common correlation approach were derived. The detection of CAR alteration by hyperventilation, their variability, and the simultaneity of the detected changes were quantified.ResultsSeventeen patients have been monitored, showing a predominant decrease in CAR due to hyperventilation in some but not all indices. The quantified variability has demonstrated that DO-based indices could be more sensitive to small changes, and a compound \u201cagreement score\u201d has indicated that most recordings (18\/20) displayed directional consistency, supporting the robustness of multimodal assessment.ConclusionsWe have demonstrated that different CAR indices lead to different interpretations and further analysis and clinical trials are merited. We call for the release of open data-sets to enable this.<\/jats:p>","DOI":"10.1117\/1.nph.13.3.035010","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:13:43Z","timestamp":1789690423000},"page":"1-31","source":"Crossref","is-referenced-by-count":0,"title":["Toward comprehensive multimodal neuromonitoring of surrogates of cerebral autoregulation in traumatic brain injury: insights from a hyperventilation protocol"],"prefix":"10.1117","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3714-1168","authenticated-orcid":false,"given":"Susanna","family":"Tagliabue","sequence":"first","affiliation":[{"name":"ICFO - Institut de Ci\u00e8ncies Fot\u00f2niques"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Martorell","family":"Ruiz","sequence":"additional","affiliation":[{"name":"ICFO - Institut de Ci\u00e8ncies Fot\u00f2niques"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-0261","authenticated-orcid":false,"given":"Jonas B.","family":"Fischer","sequence":"additional","affiliation":[{"name":"ICFO - Institut de Ci\u00e8ncies Fot\u00f2niques"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Maruccia","sequence":"additional","affiliation":[{"name":"ICFO - Institut de Ci\u00e8ncies Fot\u00f2niques"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rey-Perez","sequence":"additional","affiliation":[{"name":"Vall d'Hebron Barcelona Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Exposito","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelino","family":"Baguena","sequence":"additional","affiliation":[{"name":"Vall d'Hebron Barcelona Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-8377","authenticated-orcid":false,"given":"Jana M.","family":"Kainerstorfer","sequence":"additional","affiliation":[{"name":"Carnegie Mellon Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sahuquillo","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Univ. Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-0536","authenticated-orcid":false,"given":"Maria Antonia A.","family":"Poca","sequence":"additional","affiliation":[{"name":"Vall d'Hebron Institut de Recerca"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-1027","authenticated-orcid":false,"given":"Turgut","family":"Durduran","sequence":"additional","affiliation":[{"name":"ICFO - Institut de Ci\u00e8ncies Fot\u00f2niques"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","container-title":["Neurophotonics"],"original-title":[],"link":[{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/neurophotonics\/volume-13\/issue-03\/035010\/Toward-comprehensive-multimodal-neuromonitoring-of-surrogates-of-cerebral-autoregulation-in\/10.1117\/1.NPh.13.3.035010.full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:54:12Z","timestamp":1790193252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/journals\/neurophotonics\/volume-13\/issue-03\/035010\/Toward-comprehensive-multimodal-neuromonitoring-of-surrogates-of-cerebral-autoregulation-in\/10.1117\/1.NPh.13.3.035010.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1117\/1.nph.13.3.035010","relation":{},"ISSN":["2329-423X","2329-4248"],"issn-type":[{"value":"2329-423X","type":"print"},{"value":"2329-4248","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]}}}