{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:04:00Z","timestamp":1790269440767,"version":"4.1.0"},"reference-count":75,"publisher":"SPIE-Intl Soc Optical Eng","issue":"04","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurophoton."],"published-print":{"date-parts":[[2022,11,17]]},"abstract":"<jats:p>SignificanceBenign external hydrocephalus (BEH) is considered a self-limiting pathology with a good prognosis. However, some children present a pathological intracranial pressure (ICP) characterized by quantitative and qualitative alterations (the so-called B-waves) that can lead to neurological sequelae.AimOur purpose was to evaluate whether there were cerebral hemodynamic changes associated with ICP B-waves that could be evaluated with noninvasive neuromonitoring.ApproachWe recruited eleven patients (median age 16 months, range 7 to 55 months) with BEH and an unfavorable evolution requiring ICP monitoring. Bedside, nocturnal monitoring using near-infrared time-resolved and diffuse correlation spectroscopies synchronized to the clinical monitoring was performed.ResultsBy focusing on the timing of different ICP patterns that were identified manually by clinicians, we detected significant tissue oxygen saturation (StO2) changes (p = 0.002) and blood flow index (BFI) variability (p = 0.005) between regular and high-amplitude B-wave patterns. A blinded analysis looking for analogs of ICP patterns in BFI time traces achieved 90% sensitivity in identifying B-waves and 76% specificity in detecting the regular patterns.ConclusionsWe revealed the presence of StO2 and BFI variations\u2014detectable with optical techniques\u2014during ICP B-waves in BEH children. Finally, the feasibility of detecting ICP B-waves in hemodynamic time traces obtained noninvasively was shown.<\/jats:p>","DOI":"10.1117\/1.nph.9.4.045005","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T06:48:00Z","timestamp":1668667680000},"page":"1-21","source":"Crossref","is-referenced-by-count":6,"title":["Transcranial optical monitoring for detecting intracranial pressure alterations in children with benign external hydrocephalus: a proof-of-concept study"],"prefix":"10.1117","volume":"9","author":[{"given":"Federica","family":"Maruccia","sequence":"first","affiliation":[{"name":"Vall d\u2019Hebron Barcelona Hospital Campus, Vall d\u2019Hebron Research Institute, Neurotraumatology and Neurosurgery Research Unit, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3714-1168","authenticated-orcid":false,"given":"Susanna","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"ICFO-Insitut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santi","family":"P\u00e9rez-Hoyos","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Research Institute, Statistics and Bioinformatics Unit, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katiuska","family":"Rosas","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Barcelona Hospital Campus, Vall d\u2019Hebron Research Institute, Neurotraumatology and Neurosurgery Research Unit, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio Delgado","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Department of Pediatric Neuroradiology, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sahuquillo","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Barcelona Hospital Campus, Vall d\u2019Hebron Research Institute, Neurotraumatology and Neurosurgery Research Unit, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-1027","authenticated-orcid":false,"given":"Turgut","family":"Durduran","sequence":"additional","affiliation":[{"name":"ICFO-Insitut de Ci\u00e8ncies Fot\u00f2niques, The Barcelona Institute of Science and Technology, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-0536","authenticated-orcid":false,"given":"Maria A.","family":"Poca","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Barcelona Hospital Campus, Vall d\u2019Hebron Research Institute, Neurotraumatology and Neurosurgery Research Unit, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"189","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.4.0504"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0080-0"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.77.6.901"},{"key":"r4","first-page":"550","article-title":"Idiopathic pericerebral swelling (external hydrocephalus) of infants","author":"Azais","year":"1992"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959405"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-011-0327-4"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-021-05201-z"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1159\/000322357"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3267-z"},{"key":"r10","first-page":"701","article-title":"Ensanchamiento benigno de los espacios subaracnoideos. 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