{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:07:21Z","timestamp":1777651641489,"version":"3.51.4"},"reference-count":21,"publisher":"SPIE","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,18]]},"DOI":"10.1117\/12.2512452","type":"proceedings-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T16:00:37Z","timestamp":1552924837000},"page":"22","source":"Crossref","is-referenced-by-count":3,"title":["3D profiling of amyloid plaque-associated microglia and neuronal damage on confocal fluorescence images to aid drug discovery in Alzheimer's disease"],"prefix":"10.1117","author":[{"given":"Ilknur","family":"Icke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Z.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belma","family":"Dogdas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mirescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Bardehle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"189","reference":[{"key":"c1","year":"2019"},{"issue":"3","key":"c2","first-page":"367","article-title":"Alzheimer\u2019s disease drug development pipeline: 2017","volume":"3","author":"Cummings","year":"2017","journal-title":"Alzheimer\u2019s & Dementia: Translational Research"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.003"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020560"},{"issue":"6","key":"c8","first-page":"559","article-title":"Roles of microglia in nervous system development, plasticity, and disease","volume":"68","author":"Stevens","year":"2018","journal-title":"Special Issue: Roles of Microglia in Neural Development, Plasticity and Disease"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19699-y"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2590"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00978"},{"issue":"6176","key":"c12","article-title":"Microglia constitute a barrier that prevents neurotoxic protofibrillar a42 hotspots around plaques","volume":"6","author":"Condello","year":"2015","journal-title":"Nature Communications"},{"issue":"47","key":"c13","article-title":"Microglia limit the expansion of -amyloid plaques in a mouse model of alzheimer\u2019s disease","volume":"12","author":"Zhao","year":"2017","journal-title":"Molecular Neurodegeneration"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709069"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100710200"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24574-4"},{"key":"c18","year":"2019"},{"key":"c19","article-title":"Automatic differentiation in pytorch","author":"Paszke","year":"2017"},{"key":"c20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.003"},{"key":"c21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.10.010"}],"event":{"name":"Digital Pathology","location":"San Diego, United States","start":{"date-parts":[[2019,2,16]]},"end":{"date-parts":[[2019,2,21]]}},"container-title":["Medical Imaging 2019: Digital Pathology"],"original-title":[],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T12:58:55Z","timestamp":1554123535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spiedigitallibrary.org\/conference-proceedings-of-spie\/10956\/2512452\/3D-profiling-of-amyloid-plaque-associated-microglia-and-neuronal-damage\/10.1117\/12.2512452.full"}},"subtitle":[],"editor":[{"given":"John E.","family":"Tomaszewski","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Aaron D.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":21,"URL":"https:\/\/doi.org\/10.1117\/12.2512452","relation":{},"subject":[],"published":{"date-parts":[[2019,3,18]]}}}