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We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin\u2010like polypeptide (ELP), and nitroxide to produce an ELP\u2010nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP\u2010nitroxide conjugate has temperature\u2010dependent spectral line widths whose predictive accuracy is \u223c0.3\u200a\u00b0C (80 \u03bcM). 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