{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:48:51Z","timestamp":1791272931793,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T00:00:00Z","timestamp":1138579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2006,2]]},"abstract":"The first full single\u2010photon emission computed tomography (SPECT) imager to exploit eight compact high\u2010intrinsic\u2010resolution cadmium zinc telluride (CZT) detectors, called SemiSPECT, has been completed. Each detector consists of a CZT crystal and a customized application\u2010specific integrated circuit (ASIC). The CZT crystal is a slab with a continuous top electrode and a bottom electrode patterned into a array by photolithography. The ASIC is attached to the bottom of the CZT crystal by indium\u2010bump bonding. A bias voltage of is applied to the continuous electrode. The eight detectors are arranged in an octagonal lead\u2010shielded ring. Each pinhole in the eight\u2010pinhole aperture placed at the center of the ring is matched to each individual detector array. An object is imaged onto each detector through a pinhole, and each detector is operated independently with list\u2010mode acquisition. The imaging subject can be rotated about a vertical axis to obtain additional angular projections. The performance of SemiSPECT was characterized using . When a diameter pinhole is used, the spatial resolution on each axis is about as estimated by the Fourier crosstalk matrix, which provides an algorithm\u2010independent average resolution over the field of view. The energy resolution achieved by summing neighboring pixel signals in a window is about 10% full\u2010width\u2010at\u2010half\u2010maximum of the photopeak. The overall system sensitivity is about with the energy window of from the photopeak. Line\u2010phantom images are presented to visualize the spatial resolution provided by SemiSPECT, and images of bone, myocardium, and human tumor xenografts in mice demonstrate the feasibility of preclinical small\u2010animal studies with SemiSPECT.<\/jats:p>","DOI":"10.1118\/1.2164070","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T23:04:24Z","timestamp":1139267064000},"page":"465-474","source":"Crossref","is-referenced-by-count":103,"title":["SemiSPECT: A small\u2010animal single\u2010photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays"],"prefix":"10.1002","volume":"33","author":[{"given":"Hyunki","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars R.","family":"Furenlid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bradford","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C. J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Woolfenden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison H.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,30]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1872","article-title":"Evaluation of novel whole\u2010body high\u2010resolution rodent SPECT (Linoview) based on direct acquisition of linogram projections","volume":"46","author":"Walrand S.","year":"2005","journal-title":"J. Nucl. Med."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/39\/3\/010"},{"key":"e_1_2_8_4_1","first-page":"2282","article-title":"Ultra\u2010high resolution SPECT system using four pinhole collimators for small animal studies","volume":"36","author":"Ishizu K.","year":"1995","journal-title":"J. Nucl. Med."},{"key":"e_1_2_8_5_1","first-page":"931","article-title":"FASTSPECT: Electrical and mechanical design of a high\u2010resolution dynamic SPECT imager","volume":"2","author":"Klein W. P.","year":"1995","journal-title":"Proc. Conf. Rec. IEEE NSS\/MIC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/23.775590"},{"key":"e_1_2_8_7_1","first-page":"1164","article-title":"Performance evaluation of microPET: A high\u2010resolution lutetium oxyorthosilicate PET scanner for animal imaging","volume":"40","author":"Chatziioannou A. F.","year":"1999","journal-title":"J. Nucl. Med."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/23.940169"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2003.817948"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2002.807949"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2003.812437"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2003.817950"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/48\/11\/303"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2004.830975"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2004.823337"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2005.843615"},{"key":"e_1_2_8_17_1","first-page":"1194","article-title":"U\u2010SPECT\u2010I: A novel system for submillimeter\u2010resolution tomography with radiolabeled molecules in mice","volume":"46","author":"Beekman F. J.","year":"2005","journal-title":"J. Nucl. Med."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2002.803801"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/23.256722"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/23.682408"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/23.681995"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/23.506673"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11664-997-0229-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2002.998747"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9002(94)91637-3"},{"key":"e_1_2_8_26_1","unstructured":"2000 University of Arizona D. G. Marks Estimation methods for semiconductor gamma\u2010ray detectors"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1677252"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.804437"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.12.000834"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/39\/3\/012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.806595"},{"key":"e_1_2_8_32_1","unstructured":"2002 University of Arizona G. K. Kastis Multi\u2010modality imaging of small animals"},{"key":"e_1_2_8_33_1","unstructured":"2004 University of Arizona H. Kim SemiSPECT: A small\u2010animal SPECT imager based on eight CdZnTe detector arrays"},{"key":"e_1_2_8_34_1","volume-title":"Radiological imaging: The theory of imaging formation, detection, and processing","author":"Barrett H. H.","year":"1981"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-349450-4.50025-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/12\/4\/004"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.5.156"}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.2164070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.2164070","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1118\/1.2164070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T11:23:13Z","timestamp":1694863393000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1118\/1.2164070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,30]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1118\/1.2164070"],"URL":"https:\/\/doi.org\/10.1118\/1.2164070","archive":["Portico"],"relation":{},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"value":"0094-2405","type":"print"},{"value":"2473-4209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,30]]}}}