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In DTM, projection\u2010view images are acquired at a limited number of angles over a limited angular range and the imaged volume is reconstructed from the two\u2010dimensional projections, thus providing three\u2010dimensional structural information of the breast tissue. In this work, we investigated three representative reconstruction methods for this limited\u2010angle cone\u2010beam tomographic problem, including the backprojection (BP) method, the simultaneous algebraic reconstruction technique (SART) and the maximum likelihood method with the convex algorithm (ML\u2010convex). The SART and ML\u2010convex methods were both initialized with BP results to achieve efficient reconstruction. A second generation GE prototype tomosynthesis mammography system with a stationary digital detector was used for image acquisition. Projection\u2010view images were acquired from 21 angles in <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp7543-math-0001.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp7543:mp7543-math-0001\"\/> increments over a <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp7543-math-0002.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp7543:mp7543-math-0002\"\/> angular range. We used an American College of Radiology phantom and designed three additional phantoms to evaluate the image quality and reconstruction artifacts. In addition to visual comparison of the reconstructed images of different phantom sets, we employed the contrast\u2010to\u2010noise ratio (CNR), a line profile of features, an artifact spread function (ASF), a relative noise power spectrum (NPS), and a line object spread function (LOSF) to quantitatively evaluate the reconstruction results. It was found that for the phantoms with homogeneous background, the BP method resulted in less noisy tomosynthesized images and higher CNR values for masses than the SART and ML\u2010convex methods. However, the two iterative methods provided greater contrast enhancement for both masses and calcification, sharper LOSF, and reduced interplane blurring and artifacts with better ASF behaviors for masses. For a contrast\u2010detail phantom with heterogeneous tissue\u2010mimicking background, the BP method had strong blurring artifacts along the x\u2010ray source motion direction that obscured the contrast\u2010detail objects, while the other two methods can remove the superimposed breast structures and significantly improve object conspicuity. With a properly selected relaxation parameter, the SART method with one iteration can provide tomosynthesized images comparable to those obtained from the ML\u2010convex method with seven iterations, when BP results were used as initialization for both methods.<\/jats:p>","DOI":"10.1118\/1.2237543","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T22:21:20Z","timestamp":1159914080000},"page":"3781-3795","source":"Crossref","is-referenced-by-count":224,"title":["A comparative study of limited\u2010angle cone\u2010beam reconstruction methods for breast tomosynthesis"],"prefix":"10.1002","volume":"33","author":[{"given":"Yiheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heang\u2010Ping","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berkman","family":"Sahiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell M.","family":"Goodsitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubomir M.","family":"Hadjiiski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.205.2.9356620"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1543934"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(00)80061-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(03)80530-5"},{"key":"e_1_2_7_6_1","unstructured":"D.Kopans \u201cDigital tomosynthesis and other applications \u201d RSNA Program Book 2005 (2005) p.130."},{"key":"e_1_2_7_7_1","unstructured":"E.Rafferty \u201cBreast tomosynthesis \u201d RSNA Program Book 2005 (2005) p.141."},{"key":"e_1_2_7_8_1","unstructured":"S.Poplack C.Kogel andH.Nagy \u201cInitial experience with digital breast tomosynthesis in 99 breasts of 98 women with abnormal digital screening mammography \u201d RSNA Program Book 2005 (2005) p.317."},{"key":"e_1_2_7_9_1","unstructured":"R.Moore A.Stewart T.Wu D.Kopans E.Rafferty andD.Georgian\u2010Smith \u201cSecond\u2010generation digital breast tomosynthesis (DBT) in the screening setting: Workflow and preliminary results \u201d RSNA Program Book 2005 (2005) p.318."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016923209135135"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.105.4.903"},{"key":"e_1_2_7_12_1","first-page":"194","article-title":"Variable depth laminagraphy","volume":"6","author":"Richards A. 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