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Using deformable image registration, the three\u2010dimensional geometric transformation matrix can be derived that associates the planning image set and the images acquired on the day of treatment. Rather than replanning or moving the patient, we use the deformation matrix to morph the treatment apertures as a potential online correction method. A proof\u2010of\u2010principle study using an intensity\u2010modulated radiation therapy plan for a prostate cancer patient was conducted. The method, procedure, and algorithm of DAD are described. The dose\u2010volume histograms from the original plan, reoptimized plan, and rigid\u2010body translation plan are compared with the ones from the DAD plan. The study showed the feasibility of the DAD as a general method for both target dislocation and deformation. As compared with using couch translation to move the patient, DAD is capable of correcting both target dislocation and deformations. As compared with reoptimization, online correction using the DAD scheme could be completed within a few minutes rather than tens of minutes and the speed gain would be at a very small cost of plan quality.<\/jats:p>","DOI":"10.1118\/1.2374675","type":"journal-article","created":{"date-parts":[[2006,12,9]],"date-time":"2006-12-09T02:58:06Z","timestamp":1165633086000},"page":"4490-4498","source":"Crossref","is-referenced-by-count":64,"title":["Direct aperture deformation: An interfraction image guidance strategy"],"prefix":"10.1002","volume":"33","author":[{"given":"Yuanming","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Castro\u2010Pareja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Shekhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00248-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.09.023"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00466-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6823(1997)5:4<187::AID-ROI4>3.0.CO;2-U"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00225-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.033"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.709"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.09.044"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.03.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.09.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.03.026"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1784592"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(04)80018-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.10.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/50\/6\/009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2005.01.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1997307"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1610751"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1809768"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1935775"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00608-8"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1914543"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.09.045"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.033"},{"key":"e_1_2_7_27_1","first-page":"297","article-title":"Delivery modification as an alternative to patient repositioning in Tomotherapy","author":"Olivera G.","year":"2000","journal-title":"Proceedings of ICCR 2000"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/47\/17\/309"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1631913"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00159-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/34.56205"},{"key":"e_1_2_7_32_1","unstructured":"P. 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