{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:04:46Z","timestamp":1770627886632,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T00:00:00Z","timestamp":1166054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Radiobiological data suggest that prostate cancer has a low <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp1655-math-0001.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp1655:mp1655-math-0001\"\/> ratio. Large radiotherapy fractions may, therefore, prove more efficacious than standard radiotherapy, while radiotherapy acceleration should further improve control rates. This study describes the radiobiology of a conformal hypofractionated accelerated radiotherapy scheme for the treatment of high risk prostate cancer. Anteroposterior fields to the pelvis deliver a daily dose of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp1655-math-0002.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp1655:mp1655-math-0002\"\/>, while lateral fields confined to the prostate and seminal vesicles deliver an additional daily dose of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp1655-math-0003.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp1655:mp1655-math-0003\"\/>. Radiotherapy is accomplished within <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp1655-math-0004.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp1655:mp1655-math-0004\"\/> (15 fractions). Dose volume histograms, calculated for tissue specific <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp1655-math-0005.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp1655:mp1655-math-0005\"\/> ratios and time factors, predict a high biological dose to the prostate and seminal vesicles <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp1655-math-0006.png\" xlink:title=\"urn:x-wiley:0094-2405:media:mp1655:mp1655-math-0006\"\/>. The biological dose to normal pelvic tissues is maintained at standard levels. Radiobiological dosimetry suggests that, using hypofractionated and accelerated radiotherapy, high biological radiation dose can be given to the prostate without overdosing normal tissues.<\/jats:p>","DOI":"10.1118\/1.2401655","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T19:21:12Z","timestamp":1167938472000},"page":"76-80","source":"Crossref","is-referenced-by-count":6,"title":["Biological dose volume histograms during conformal hypofractionated accelerated radiotherapy for prostate cancer"],"prefix":"10.1002","volume":"34","author":[{"given":"Michael I.","family":"Koukourakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Abatzoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros","family":"Touloupidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Manavis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00438-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0360-3016(01)01607-8","article-title":"Is alpha\/beta for prostate tumors really low?","volume":"50","author":"Fowler J.","journal-title":"Int. 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