{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T07:47:54Z","timestamp":1694936874823},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T00:00:00Z","timestamp":1187136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>We investigated the amplification of discrepancy when using multiple shots of the same collimator size helmet, by comparing dose plans in the Leksell GammaPlan<jats:sup>\u00ae<\/jats:sup> employing the default single\u2010beam dose profiles and the Monte Carlo generated single\u2010beam profiles. Four collimator helmets were studied. The results show that the largest amplification of discrepancy with multiple shots was found with the 8 mm collimator because of the largest discrepancy of its single\u2010beam dose profile. The amplification of discrepancy is significant when tumor volumes increase but insignificant when the tumor volumes are in an elongated shape. Using close shot overlapping strategy (i.e., more shots close packed together) shows no observable increase in the amplification of discrepancy. For the best quality of Leksell Gamma Knife<jats:sup>\u00ae<\/jats:sup> radiosurgery, it is suggested that the single\u2010beam dose profiles should be refined, especially the 8 mm collimator, to prevent error amplification when using multiple collimator shots.<\/jats:p>","DOI":"10.1118\/1.2766760","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T22:13:38Z","timestamp":1188944018000},"page":"3556-3561","source":"Crossref","is-referenced-by-count":1,"title":["Comparative study of treatment dose plans after the refinement of Leksell Gamma Knife<sup>\u00ae<\/sup> single\u2010beam dose profiles"],"prefix":"10.1002","volume":"34","author":[{"given":"Joel Y. C.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. P.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T. K.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598347"},{"key":"e_1_2_5_3_1","unstructured":"Leksell Gamma Unit\u2014User's Manual 1. Elekta 1992."},{"key":"e_1_2_5_4_1","unstructured":"Elekta Instrument\u2014Stockholm Registry of Radioactive Sealed Sources and Devices Safety Evaluation of Sealed Source April1984."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1059-4"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969\u20108043(99)00285\u20107"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/50\/6\/013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1078\/0939-3889-00313"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3171\/jns.2002.97.supplement_5.0582","article-title":"Three\u2010dimensional dose verification using BANG gel: A clinical example","volume":"97","author":"Scheib S. G.","year":"2002","journal-title":"J. Neurosurg."},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1881812"},{"key":"e_1_2_5_11_1","unstructured":"Eleka Leksell Gamma Knife manufacturer (personal communication)."}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.2766760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1118%2F1.2766760","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1118\/1.2766760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T01:55:37Z","timestamp":1694915737000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1118\/1.2766760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,15]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1118\/1.2766760"],"URL":"https:\/\/doi.org\/10.1118\/1.2766760","archive":["Portico"],"relation":{},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"value":"0094-2405","type":"print"},{"value":"2473-4209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,15]]}}}