{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:16:01Z","timestamp":1773922561086,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T00:00:00Z","timestamp":1207699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>The issue of neutron leakage has recently been raised in connection with dedicated electron\u2010only linear accelerators used for intraoperative radiation therapy (IORT). In particular, concern has been expressed about the degree of neutron production at energies of 10 MeV and higher due to the need for additional, perhaps permanent, shielding in the room in which the device is operated. In particular, three mobile linear accelerators available commercially offer electron energies at or above the neutron threshold, one at 9 MeV, one at 10 MeV, and the third at 12 MeV. To investigate this problem, neutron leakage has been measured around the head of two types of electron accelerators at a distance of 1 m from the target at azimuthal angles of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0001.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0001\"\/>, <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0002.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0002\"\/>, <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0003.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0003\"\/>, <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0004.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0004\"\/>, and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0005.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0005\"\/>. The first is a dedicated electron\u2010only (nonmobile) machine with electron energies of 6 (not used here), 9, 12, 15, and 18 MeV and the second a conventional machine with electron energies of 6 (also not used here), 9, 12, 16, and 20 MeV. Measurements were made using neutron bubble detectors and track\u2010etch detectors. For electron beams from a conventional accelerator, the neutron leakage in the forward direction in Sv\/Gy is <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0006.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0006\"\/> at 12 MeV, <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0007.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0007\"\/> at 16 MeV, and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0008.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0008\"\/> at 20 MeV, assuming a quality factor (RBE) of 10. For azimuthal angles <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0009.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0009\"\/>, the leakage is almost angle independent [<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0010.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0010\"\/> at 12 MeV; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0011.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0011\"\/> at 16 MeV, and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0012.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0012\"\/> at 20 MeV]. For the electron\u2010only machine, the neutron leakage was lower than for the conventional linac, but also independent of azimuthal angle for angles <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0013.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0013\"\/>: {[<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0014.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0014\"\/>: <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0015.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0015\"\/> at 12 MeV; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0016.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0016\"\/> at 15 MeV; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0017.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0017\"\/> at 18 MeV]; [other angles: <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0018.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0018\"\/> at 12 MeV; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0019.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0019\"\/> at 15 MeV; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0020.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0020\"\/> at 18 MeV]}. Using the upper limit of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0021.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0021\"\/> at 12 MeV for the IORT machine for azimuthal angles <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0022.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0022\"\/> and assuming a workload of 200 Gy\/wk and an inverse square factor of 10, the neutron dose equivalent is calculated to be 0.012 mSv\/wk. For the primary beam at 12 MeV <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0023.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0023\"\/>, the <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mp8144-math-0024.png\" xlink:title=\"urn:x-wiley:00942405:media:mp8144:mp8144-math-0024\"\/> higher dose would be compensated by the attenuation of a primary beam stopper in a mobile linear accelerator. These neutron radiation levels are below regulatory values (National Council on Radiation Protection and Measurements, \u201cLimitation of exposure to ionizing radiation,\u201d NCRP Report No. 116, NCRP Bethesda, MD, 1993).<\/jats:p>","DOI":"10.1118\/1.2898144","type":"journal-article","created":{"date-parts":[[2008,5,5]],"date-time":"2008-05-05T22:23:12Z","timestamp":1210026192000},"page":"1711-1717","source":"Crossref","is-referenced-by-count":27,"title":["Measurement of the neutron leakage from a dedicated intraoperative radiation therapy electron linear accelerator and a conventional linear accelerator for 9, 12, 15(16), and 18(20) MeV electron energies"],"prefix":"10.1002","volume":"35","author":[{"given":"Adnan K.","family":"Jaradat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Biggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.0255"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(95)00280\u2010C"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(81)90003-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90460-2"},{"key":"e_1_2_6_6_1","unstructured":"National Council on Radiation Protection and Measurements \u201cNeutron contamination from medical accelerators \u201d NCRP Report No. 79 NCRP Bethesda Maryland 1984."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1120\/1.1385129"},{"key":"e_1_2_6_8_1","first-page":"489","article-title":"Radiation exposure of personnel during intra\u2010operative radiotherapy (IORT): Radiation protection aspects","volume":"23","author":"Strigari L.","year":"2004","journal-title":"J. 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