{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T10:59:29Z","timestamp":1778410769119,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:00:00Z","timestamp":1298505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2011,3]]},"abstract":"Purpose:<\/jats:title>The authors assembled a prototype compact gamma\u2010ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera.<\/jats:p><\/jats:sec>Methods:<\/jats:title>The room\u2010temperature CdTe pixel detector (1 mm thick) has square pixels arranged with a pitch (sensitive area ), coupled pixel\u2010by\u2010pixel via bump\u2010bonding to the Medipix2 photon\u2010counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife\u2010edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diameter at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin\u2010to\u2010collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low\u2010energy threshold of about 20 keV.<\/jats:p><\/jats:sec>Results:<\/jats:title>For, at 50 mm distance, a background\u2010subtracted sensitivity of and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq and prior localization with standard gamma camera lymphoscintigraphy.<\/jats:p><\/jats:sec>Conclusions:<\/jats:title>The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at shorter distances from the patient skin.<\/jats:p><\/jats:sec>","DOI":"10.1118\/1.3555034","type":"journal-article","created":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T14:55:04Z","timestamp":1299250504000},"page":"1547-1560","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of a CdTe semiconductor based compact gamma camera for sentinel lymph node imaging"],"prefix":"10.1002","volume":"38","author":[{"given":"Paolo","family":"Russo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta S.","family":"Curion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Mettivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Aurilio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corradina","family":"Carac\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Aloj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Secondo","family":"Lastoria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdip.2006.12.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2004.11.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001\u20102998(97)80036\u20100"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012782"},{"key":"e_1_2_7_8_1","first-page":"1414","article-title":"Procedure guidelines for lymphoscintigraphy and the use of intraoperative gamma probe for sentinel lymph node localization in melanoma of intermediate thickness 1.0","volume":"43","author":"Alazraki N.","year":"2002","journal-title":"J. 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